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- W2019279707 abstract "Electroconvulsive shock (ECS) may affect several neurotransmitter systems in brain, including the GABAergic inhibitory system. We used a quantitative PCR-based assay to evaluate mRNAs for five GABAa receptor subunits at 2 to 24 h after ECS. mRNAs for the alpha 1 and beta 2 subunits were significantly increased in cerebellum at 4 and 8 h after ECS, and returned to control levels at 24 h. No changes were observed in alpha 2, beta 3, gamma 1, or gamma 2 subunits, and no changes in any subunit evaluated were observed in cortex or hippocampus. These data corroborate prior results obtained for the alpha 1 subunit using Northern hybridization, and illustrate the utility of the PCR assay in quantitating low-abundance mRNAs." @default.
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- W2019279707 modified "2023-10-14" @default.
- W2019279707 title "Electroconvulsive shock alters GABAA receptor subunit mRNAs: Use of quantitative PCR methodology" @default.
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- W2019279707 doi "https://doi.org/10.1016/0361-9230(93)90101-g" @default.
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