FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019282892> ?p ?o ?g. }

• W2019282892 endingPage "152" @default.
• W2019282892 startingPage "145" @default.
• W2019282892 abstract "Hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine (NIC) are sexually diergic: Female rats have higher adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than do males. In the present study we determined HPA responses in male and female rats following single doses of NIC, a single-dose of NIC immediately following continuous NIC for two weeks, and NIC withdrawal by single-dose mecamylamine (MEC) following continuous NIC infusion for two weeks. Blood sampling occurred before and after MEC and NIC administrations for the determination of ACTH and CORT. In accordance with our previous findings, female ACTH and CORT responses to single-dose NIC were greater than male responses. This sex difference remained after single-dose NIC followed continuous NIC infusion, but HPA responses in both sexes were significantly lower in magnitude and duration than in the single-dose NIC alone groups. Sex differences also were observed following NIC withdrawal by MEC: the HPA responses to pretreatment with MEC were significantly higher in magnitude and duration in the continuous NIC groups than in the single-dose NIC groups. These results demonstrate that HPA responses to NIC are reduced and transient following continuous NIC infusion but are enhanced and sustained following NIC withdrawal by MEC after continuous NIC, suggesting that NIC habituation and withdrawal influence the stress responses in a diergic manner. These findings highlight the importance of sex differences in the effect of NIC on HPA axis activity and stress responsiveness, which may have implications for directing NIC-addiction treatment specifically towards men and women." @default.
• W2019282892 created "2016-06-24" @default.
• W2019282892 creator A5004369157 @default.
• W2019282892 creator A5009830710 @default.
• W2019282892 creator A5010277760 @default.
• W2019282892 creator A5016934859 @default.
• W2019282892 creator A5023604224 @default.
• W2019282892 creator A5078536928 @default.
• W2019282892 date "2011-05-01" @default.
• W2019282892 modified "2023-10-02" @default.
• W2019282892 title "Sexually diergic hypothalamic–pituitary–adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats" @default.
• W2019282892 cites W1544301323 @default.
• W2019282892 cites W179866513 @default.
• W2019282892 cites W1968473948 @default.
• W2019282892 cites W1969862544 @default.
• W2019282892 cites W1970290009 @default.
• W2019282892 cites W1971746055 @default.
• W2019282892 cites W1972548981 @default.
• W2019282892 cites W1973660019 @default.
• W2019282892 cites W1979614696 @default.
• W2019282892 cites W1981382840 @default.
• W2019282892 cites W1981702744 @default.
• W2019282892 cites W1984504275 @default.
• W2019282892 cites W1986757550 @default.
• W2019282892 cites W1986867990 @default.
• W2019282892 cites W1989430669 @default.
• W2019282892 cites W1990985114 @default.
• W2019282892 cites W1993087404 @default.
• W2019282892 cites W1993638721 @default.
• W2019282892 cites W1993992003 @default.
• W2019282892 cites W2003961298 @default.
• W2019282892 cites W2004192630 @default.
• W2019282892 cites W2004214768 @default.
• W2019282892 cites W2014327575 @default.
• W2019282892 cites W2014619876 @default.
• W2019282892 cites W2016312674 @default.
• W2019282892 cites W2017309344 @default.
• W2019282892 cites W2020582575 @default.
• W2019282892 cites W2021139758 @default.
• W2019282892 cites W2022329830 @default.
• W2019282892 cites W2022902979 @default.
• W2019282892 cites W2023283315 @default.
• W2019282892 cites W2027002868 @default.
• W2019282892 cites W2028068179 @default.
• W2019282892 cites W2034160322 @default.
• W2019282892 cites W2035294814 @default.
• W2019282892 cites W2036345851 @default.
• W2019282892 cites W2039448408 @default.
• W2019282892 cites W2039583040 @default.
• W2019282892 cites W2043794850 @default.
• W2019282892 cites W2054323635 @default.
• W2019282892 cites W2055369604 @default.
• W2019282892 cites W2059022383 @default.
• W2019282892 cites W2060644077 @default.
• W2019282892 cites W2062889920 @default.
• W2019282892 cites W2072388928 @default.
• W2019282892 cites W2073704076 @default.
• W2019282892 cites W2075155139 @default.
• W2019282892 cites W2076977052 @default.
• W2019282892 cites W2078045472 @default.
• W2019282892 cites W2078653144 @default.
• W2019282892 cites W2083737326 @default.
• W2019282892 cites W2083993994 @default.
• W2019282892 cites W2085180109 @default.
• W2019282892 cites W2093764476 @default.
• W2019282892 cites W2093867596 @default.
• W2019282892 cites W2099323802 @default.
• W2019282892 cites W2137402534 @default.
• W2019282892 cites W2146995132 @default.
• W2019282892 cites W2147303576 @default.
• W2019282892 cites W2151079096 @default.
• W2019282892 cites W2155263358 @default.
• W2019282892 cites W2167035822 @default.
• W2019282892 cites W2314642171 @default.
• W2019282892 cites W2419065156 @default.
• W2019282892 cites W4241495503 @default.
• W2019282892 cites W4244101447 @default.
• W2019282892 cites W2082231722 @default.
• W2019282892 doi "https://doi.org/10.1016/j.brainresbull.2011.03.001" @default.
• W2019282892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3109189" @default.
• W2019282892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21396990" @default.
• W2019282892 hasPublicationYear "2011" @default.
• W2019282892 type Work @default.
• W2019282892 sameAs 2019282892 @default.
• W2019282892 citedByCount "34" @default.
• W2019282892 countsByYear W20192828922012 @default.
• W2019282892 countsByYear W20192828922013 @default.
• W2019282892 countsByYear W20192828922014 @default.
• W2019282892 countsByYear W20192828922015 @default.
• W2019282892 countsByYear W20192828922016 @default.
• W2019282892 countsByYear W20192828922017 @default.
• W2019282892 countsByYear W20192828922018 @default.
• W2019282892 countsByYear W20192828922019 @default.
• W2019282892 countsByYear W20192828922020 @default.
• W2019282892 countsByYear W20192828922021 @default.
• W2019282892 countsByYear W20192828922022 @default.
• W2019282892 countsByYear W20192828922023 @default.
• W2019282892 crossrefType "journal-article" @default.

• next