FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019289099> ?p ?o ?g. }

• W2019289099 endingPage "15830" @default.
• W2019289099 startingPage "15825" @default.
• W2019289099 abstract "Through an immune-mediated graft-versus-leukemia effect, allogeneic hematopoietic stem cell transplantation (HSCT) affords durable clinical benefits for many patients with hematologic malignancies. Nonetheless, subjects with high-risk acute myeloid leukemia or advanced myelodysplasia often relapse, underscoring the need to intensify tumor immunity within this cohort. In preclinical models, allogeneic HSCT followed by vaccination with irradiated tumor cells engineered to secrete GM-CSF generates a potent antitumor effect without exacerbating the toxicities of graft-versus-host disease (GVHD). To test whether this strategy might be similarly active in humans, we conducted a Phase I clinical trial in which high-risk acute myeloid leukemia or myelodysplasia patients were immunized with irradiated, autologous, GM-CSF-secreting tumor cells early after allogeneic, nonmyeloablative HSCT. Despite the administration of a calcineurin inhibitor as prophylaxis against GVHD, vaccination elicited local and systemic reactions that were qualitatively similar to those previously observed in nontransplanted, immunized solid-tumor patients. While the frequencies of acute and chronic GVHD were not increased, 9 of 10 subjects who completed vaccination achieved durable complete remissions, with a median follow-up of 26 months (range 12-43 months). Six long-term responders showed marked decreases in the levels of soluble NKG2D ligands, and 3 demonstrated normalization of cytotoxic lymphocyte NKG2D expression as a function of treatment. Together, these results establish the safety and immunogenicity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic HSCT, and raise the possibility that this combinatorial immunotherapy might potentiate graft-versus-leukemia in patients." @default.
• W2019289099 created "2016-06-24" @default.
• W2019289099 creator A5005876566 @default.
• W2019289099 creator A5008718116 @default.
• W2019289099 creator A5014155836 @default.
• W2019289099 creator A5025710827 @default.
• W2019289099 creator A5028608171 @default.
• W2019289099 creator A5029278364 @default.
• W2019289099 creator A5029390145 @default.
• W2019289099 creator A5031812464 @default.
• W2019289099 creator A5046141073 @default.
• W2019289099 creator A5054037976 @default.
• W2019289099 creator A5060096615 @default.
• W2019289099 creator A5068050082 @default.
• W2019289099 creator A5074589634 @default.
• W2019289099 creator A5077262744 @default.
• W2019289099 creator A5077581687 @default.
• W2019289099 creator A5078140044 @default.
• W2019289099 creator A5088578313 @default.
• W2019289099 date "2009-09-15" @default.
• W2019289099 modified "2023-10-02" @default.
• W2019289099 title "Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation" @default.
• W2019289099 cites W1509514214 @default.
• W2019289099 cites W1519385930 @default.
• W2019289099 cites W1574888913 @default.
• W2019289099 cites W1978062566 @default.
• W2019289099 cites W2021986444 @default.
• W2019289099 cites W2030830121 @default.
• W2019289099 cites W2040041834 @default.
• W2019289099 cites W2046414594 @default.
• W2019289099 cites W2053402248 @default.
• W2019289099 cites W2053453932 @default.
• W2019289099 cites W2063495860 @default.
• W2019289099 cites W2064006160 @default.
• W2019289099 cites W2064826198 @default.
• W2019289099 cites W2064920472 @default.
• W2019289099 cites W2082983645 @default.
• W2019289099 cites W2084972210 @default.
• W2019289099 cites W2087025602 @default.
• W2019289099 cites W2098802845 @default.
• W2019289099 cites W2105011122 @default.
• W2019289099 cites W2112897941 @default.
• W2019289099 cites W2118322536 @default.
• W2019289099 cites W2123223147 @default.
• W2019289099 cites W2124373740 @default.
• W2019289099 cites W2131874142 @default.
• W2019289099 cites W2139184776 @default.
• W2019289099 cites W2139282511 @default.
• W2019289099 cites W2145993965 @default.
• W2019289099 cites W2153512326 @default.
• W2019289099 cites W2155189639 @default.
• W2019289099 cites W2156222101 @default.
• W2019289099 cites W2160666689 @default.
• W2019289099 cites W2166970460 @default.
• W2019289099 doi "https://doi.org/10.1073/pnas.0908358106" @default.
• W2019289099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747203" @default.
• W2019289099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19717467" @default.
• W2019289099 hasPublicationYear "2009" @default.
• W2019289099 type Work @default.
• W2019289099 sameAs 2019289099 @default.
• W2019289099 citedByCount "98" @default.
• W2019289099 countsByYear W20192890992012 @default.
• W2019289099 countsByYear W20192890992013 @default.
• W2019289099 countsByYear W20192890992014 @default.
• W2019289099 countsByYear W20192890992015 @default.
• W2019289099 countsByYear W20192890992016 @default.
• W2019289099 countsByYear W20192890992017 @default.
• W2019289099 countsByYear W20192890992018 @default.
• W2019289099 countsByYear W20192890992019 @default.
• W2019289099 countsByYear W20192890992020 @default.
• W2019289099 countsByYear W20192890992021 @default.
• W2019289099 countsByYear W20192890992022 @default.
• W2019289099 countsByYear W20192890992023 @default.
• W2019289099 crossrefType "journal-article" @default.
• W2019289099 hasAuthorship W2019289099A5005876566 @default.
• W2019289099 hasAuthorship W2019289099A5008718116 @default.
• W2019289099 hasAuthorship W2019289099A5014155836 @default.
• W2019289099 hasAuthorship W2019289099A5025710827 @default.
• W2019289099 hasAuthorship W2019289099A5028608171 @default.
• W2019289099 hasAuthorship W2019289099A5029278364 @default.
• W2019289099 hasAuthorship W2019289099A5029390145 @default.
• W2019289099 hasAuthorship W2019289099A5031812464 @default.
• W2019289099 hasAuthorship W2019289099A5046141073 @default.
• W2019289099 hasAuthorship W2019289099A5054037976 @default.
• W2019289099 hasAuthorship W2019289099A5060096615 @default.
• W2019289099 hasAuthorship W2019289099A5068050082 @default.
• W2019289099 hasAuthorship W2019289099A5074589634 @default.
• W2019289099 hasAuthorship W2019289099A5077262744 @default.
• W2019289099 hasAuthorship W2019289099A5077581687 @default.
• W2019289099 hasAuthorship W2019289099A5078140044 @default.
• W2019289099 hasAuthorship W2019289099A5088578313 @default.
• W2019289099 hasBestOaLocation W20192890991 @default.
• W2019289099 hasConcept C126322002 @default.
• W2019289099 hasConcept C203014093 @default.
• W2019289099 hasConcept C22070199 @default.
• W2019289099 hasConcept C2776863199 @default.
• W2019289099 hasConcept C2777408962 @default.
• W2019289099 hasConcept C2777701055 @default.

• next