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- W2019291117 abstract "Abstract The effects of an H 1 antagonist (chlorpheniramine) and an H 2 antagonist (cimetidine) alone or in combination, and of ASA on the ICR and the LCR to timothy or ragweed were evaluated. HCRs were also applied at each testing. The H 1 blocker alone significantly inhibited the HCR and the ICR, but not the LCR. The H 2 blocker by itself had no effect on HCR, ICR, or LCR. The addition of the H 2 to the H 1 blocker markedly increased the H 1 blocker's inhibition of the HCR and ICR and completely obliterated the LCR in most subjects. These findings, which could not be explained by simple additive effects, suggest a synergistic activity of the H 1 and the H 2 blocker combination. ASA had no effect on HCR, ICR, or LCR, casting doubt on the possible role of prostaglandins in the LCR." @default.
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- W2019291117 date "1980-02-01" @default.
- W2019291117 modified "2023-09-27" @default.
- W2019291117 title "An evaluation of the pharmacologic inhibition of the immediate and late cutaneous reaction to allergen" @default.
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- W2019291117 doi "https://doi.org/10.1016/0091-6749(80)90195-5" @default.
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