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• W2019291621 endingPage "720" @default.
• W2019291621 startingPage "708" @default.
• W2019291621 abstract "Nitric oxide produced by neuronal nitric oxide synthase (nNOS) in the spinal cord is required for development of hyperalgesia in inflammatory and neuropathic pain states. nNOS is expressed by some dorsal horn neurons, and an early study that used a histochemical method to identify these cells suggested that they were mainly inhibitory interneurons. We have carried out a quantitative analysis of nNOS-immunoreactivity in laminae I-III of the rat dorsal horn, to determine the proportion of inhibitory and excitatory neurons and axonal boutons that express the protein. nNOS was present in ∼5% of neurons in laminae I and III, and 18% of those in lamina II. Although most cells with strong nNOS immunostaining were GABA-immunoreactive, two-thirds of the nNOS-positive cells in lamina II and half of those in lamina III were not GABAergic, and some of these expressed protein kinase Cγ (PKCγ). We estimate that nNOS is present in 17-19% of the inhibitory interneurons in laminae I-II, and 6% of those in lamina III. However, our results suggest that nNOS is also expressed at a relatively low level by a significant proportion (∼17%) of excitatory interneurons in lamina II. nNOS was seldom seen in boutons that contained vesicular glutamate transporter 2, which is expressed by excitatory interneurons, but was co-localised with the vesicular GABA transporter (VGAT, a marker for GABAergic and glycinergic axons). nNOS was detected in 13% of VGAT boutons in lamina I and in 7-8% of those in laminae II-III. However, it was only found in 2-4% of the VGAT boutons that were presynaptic to PKCγ-expressing interneurons in this region. These results indicate that nNOS is more widely expressed than previously thought, being present in both inhibitory and excitatory neurons. They provide further evidence that axons of neurochemically defined populations of inhibitory interneuron are selective in their post-synaptic targets." @default.
• W2019291621 created "2016-06-24" @default.
• W2019291621 creator A5017811687 @default.
• W2019291621 creator A5038646127 @default.
• W2019291621 creator A5043970902 @default.
• W2019291621 creator A5085326035 @default.
• W2019291621 date "2011-09-01" @default.
• W2019291621 modified "2023-10-14" @default.
• W2019291621 title "A quantitative study of neuronal nitric oxide synthase expression in laminae I–III of the rat spinal dorsal horn" @default.
• W2019291621 cites W1496464433 @default.
• W2019291621 cites W1505732106 @default.
• W2019291621 cites W1556754351 @default.
• W2019291621 cites W1788084167 @default.
• W2019291621 cites W1945096581 @default.
• W2019291621 cites W1965948569 @default.
• W2019291621 cites W1967739579 @default.
• W2019291621 cites W1968759033 @default.
• W2019291621 cites W1968789032 @default.
• W2019291621 cites W1969014948 @default.
• W2019291621 cites W1969603798 @default.
• W2019291621 cites W1973235352 @default.
• W2019291621 cites W1975724241 @default.
• W2019291621 cites W1977394169 @default.
• W2019291621 cites W1978648371 @default.
• W2019291621 cites W1987123427 @default.
• W2019291621 cites W1988054281 @default.
• W2019291621 cites W1990832845 @default.
• W2019291621 cites W1995796629 @default.
• W2019291621 cites W1996470411 @default.
• W2019291621 cites W1996627744 @default.
• W2019291621 cites W1997450735 @default.
• W2019291621 cites W1998172352 @default.
• W2019291621 cites W2001982896 @default.
• W2019291621 cites W2004558157 @default.
• W2019291621 cites W2008364921 @default.
• W2019291621 cites W2011831455 @default.
• W2019291621 cites W2014260438 @default.
• W2019291621 cites W2015561162 @default.
• W2019291621 cites W2016556575 @default.
• W2019291621 cites W2017974613 @default.
• W2019291621 cites W2019313125 @default.
• W2019291621 cites W2020084860 @default.
• W2019291621 cites W2022297536 @default.
• W2019291621 cites W2026594181 @default.
• W2019291621 cites W2029492124 @default.
• W2019291621 cites W2029706214 @default.
• W2019291621 cites W2031811175 @default.
• W2019291621 cites W2033449042 @default.
• W2019291621 cites W2034140178 @default.
• W2019291621 cites W2037468514 @default.
• W2019291621 cites W2038152105 @default.
• W2019291621 cites W2041272952 @default.
• W2019291621 cites W2045300940 @default.
• W2019291621 cites W2051798639 @default.
• W2019291621 cites W2055546532 @default.
• W2019291621 cites W2055705346 @default.
• W2019291621 cites W2056262623 @default.
• W2019291621 cites W2059635921 @default.
• W2019291621 cites W2061340270 @default.
• W2019291621 cites W2063223361 @default.
• W2019291621 cites W2063614313 @default.
• W2019291621 cites W2064115030 @default.
• W2019291621 cites W2064776460 @default.
• W2019291621 cites W2066996444 @default.
• W2019291621 cites W2069213445 @default.
• W2019291621 cites W2070349308 @default.
• W2019291621 cites W2071008563 @default.
• W2019291621 cites W2074547495 @default.
• W2019291621 cites W2077191265 @default.
• W2019291621 cites W2084414231 @default.
• W2019291621 cites W2087538286 @default.
• W2019291621 cites W2088062805 @default.
• W2019291621 cites W2090612180 @default.
• W2019291621 cites W2092152852 @default.
• W2019291621 cites W2092239347 @default.
• W2019291621 cites W2092439619 @default.
• W2019291621 cites W2093368672 @default.
• W2019291621 cites W2096194006 @default.
• W2019291621 cites W2102729306 @default.
• W2019291621 cites W2103302443 @default.
• W2019291621 cites W2106255703 @default.
• W2019291621 cites W2108009593 @default.
• W2019291621 cites W2109991720 @default.
• W2019291621 cites W2111919302 @default.
• W2019291621 cites W2115761515 @default.
• W2019291621 cites W2126764967 @default.
• W2019291621 cites W2128091183 @default.
• W2019291621 cites W2128692107 @default.
• W2019291621 cites W2147944067 @default.
• W2019291621 cites W2152299618 @default.
• W2019291621 cites W2158496649 @default.
• W2019291621 cites W2164333230 @default.
• W2019291621 cites W2171147017 @default.
• W2019291621 doi "https://doi.org/10.1016/j.neuroscience.2011.07.011" @default.
• W2019291621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3183229" @default.
• W2019291621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21763759" @default.
• W2019291621 hasPublicationYear "2011" @default.
• W2019291621 type Work @default.

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