FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019291640> ?p ?o ?g. }

• W2019291640 endingPage "171" @default.
• W2019291640 startingPage "166" @default.
• W2019291640 abstract "The aim of the study was to evaluate the effect of losartan therapy on endothelial function by measuring serum nitric oxide (NO) levels and urinary excretion of NO in patients with essential hypertension. A group of 30 untreated stage 2 hypertensive patients (15 males and 15 females; age, 51.3 +/- 1.5 years) were included in the study. Office systolic and diastolic blood pressure (BP) was measured by using a mercury sphygmomanometer according to phase I and V of Korotkoff sounds. NO levels in serum and 24-hour urine were determined at baseline and after 6 weeks of daily dosing with losartan (50-100 mg). Losartan therapy resulted in a significant fall in systolic/diastolic BP (from 169.7 +/- 4.1/105 +/- 1.8 mm Hg at baseline to 146 +/- 2.7/91 +/- 1.9 mm Hg at the end of losartan treatment; P < 0.001). The therapy also caused significant increases in both serum NO level (32.74 +/- 3.01 microM/L at baseline versus 79.04 +/- 5.17 microM/L; P < 0.001 after therapy) and urinary NO excretion (58.21 +/- 3.72 microM/L at baseline versus 113.21 +/- 8.63 microM/L; P < 0.001 after therapy). Losartan therapy also reduced serum malondialdehyde (MDA), which is a measure of oxidative stress, by 0.201 nM (15.3%; P = 0.009). Losartan at a dose of 50 to 100 mg per day was effective in reducing elevated BP. The increase in serum NO levels and urinary NO excretion and a decrease in serum MDA levels by losartan treatment indicate a reduction in oxidative stress and enhances NO availability, both of which improve endothelial function. Thus, losartan therapy improves endothelial function in hypertensive patients with essential hypertension." @default.
• W2019291640 created "2016-06-24" @default.
• W2019291640 creator A5009302632 @default.
• W2019291640 creator A5016908257 @default.
• W2019291640 creator A5020945695 @default.
• W2019291640 creator A5038899424 @default.
• W2019291640 creator A5046644166 @default.
• W2019291640 creator A5057389405 @default.
• W2019291640 creator A5060400452 @default.
• W2019291640 creator A5065646513 @default.
• W2019291640 creator A5084751651 @default.
• W2019291640 date "2007-03-01" @default.
• W2019291640 modified "2023-09-28" @default.
• W2019291640 title "Effect of Losartan Therapy on Endothelial Function in Hypertensive Patients" @default.
• W2019291640 cites W1507715221 @default.
• W2019291640 cites W1528557278 @default.
• W2019291640 cites W1971377175 @default.
• W2019291640 cites W1974332277 @default.
• W2019291640 cites W1976555160 @default.
• W2019291640 cites W1982033190 @default.
• W2019291640 cites W1984629678 @default.
• W2019291640 cites W1988924001 @default.
• W2019291640 cites W1991036211 @default.
• W2019291640 cites W1995332350 @default.
• W2019291640 cites W1996413553 @default.
• W2019291640 cites W2002717483 @default.
• W2019291640 cites W2010037068 @default.
• W2019291640 cites W2010374269 @default.
• W2019291640 cites W2021994429 @default.
• W2019291640 cites W2027457721 @default.
• W2019291640 cites W2030364592 @default.
• W2019291640 cites W2041034845 @default.
• W2019291640 cites W2049425017 @default.
• W2019291640 cites W2068139611 @default.
• W2019291640 cites W2073497750 @default.
• W2019291640 cites W2078725437 @default.
• W2019291640 cites W2079891784 @default.
• W2019291640 cites W2081233931 @default.
• W2019291640 cites W2081508447 @default.
• W2019291640 cites W2083601587 @default.
• W2019291640 cites W2085137779 @default.
• W2019291640 cites W2091193879 @default.
• W2019291640 cites W2098328918 @default.
• W2019291640 cites W2115475740 @default.
• W2019291640 cites W2120802920 @default.
• W2019291640 cites W2122052038 @default.
• W2019291640 cites W2126757938 @default.
• W2019291640 cites W2153889396 @default.
• W2019291640 doi "https://doi.org/10.1097/01.pap.0000249919.44604.e1" @default.
• W2019291640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17414585" @default.
• W2019291640 hasPublicationYear "2007" @default.
• W2019291640 type Work @default.
• W2019291640 sameAs 2019291640 @default.
• W2019291640 citedByCount "6" @default.
• W2019291640 countsByYear W20192916402018 @default.
• W2019291640 countsByYear W20192916402019 @default.
• W2019291640 countsByYear W20192916402022 @default.
• W2019291640 crossrefType "journal-article" @default.
• W2019291640 hasAuthorship W2019291640A5009302632 @default.
• W2019291640 hasAuthorship W2019291640A5016908257 @default.
• W2019291640 hasAuthorship W2019291640A5020945695 @default.
• W2019291640 hasAuthorship W2019291640A5038899424 @default.
• W2019291640 hasAuthorship W2019291640A5046644166 @default.
• W2019291640 hasAuthorship W2019291640A5057389405 @default.
• W2019291640 hasAuthorship W2019291640A5060400452 @default.
• W2019291640 hasAuthorship W2019291640A5065646513 @default.
• W2019291640 hasAuthorship W2019291640A5084751651 @default.
• W2019291640 hasConcept C10146269 @default.
• W2019291640 hasConcept C126322002 @default.
• W2019291640 hasConcept C126894567 @default.
• W2019291640 hasConcept C134018914 @default.
• W2019291640 hasConcept C2776151105 @default.
• W2019291640 hasConcept C2778401633 @default.
• W2019291640 hasConcept C2780288358 @default.
• W2019291640 hasConcept C2908929049 @default.
• W2019291640 hasConcept C519581460 @default.
• W2019291640 hasConcept C57900726 @default.
• W2019291640 hasConcept C71924100 @default.
• W2019291640 hasConcept C77411442 @default.
• W2019291640 hasConcept C84393581 @default.
• W2019291640 hasConceptScore W2019291640C10146269 @default.
• W2019291640 hasConceptScore W2019291640C126322002 @default.
• W2019291640 hasConceptScore W2019291640C126894567 @default.
• W2019291640 hasConceptScore W2019291640C134018914 @default.
• W2019291640 hasConceptScore W2019291640C2776151105 @default.
• W2019291640 hasConceptScore W2019291640C2778401633 @default.
• W2019291640 hasConceptScore W2019291640C2780288358 @default.
• W2019291640 hasConceptScore W2019291640C2908929049 @default.
• W2019291640 hasConceptScore W2019291640C519581460 @default.
• W2019291640 hasConceptScore W2019291640C57900726 @default.
• W2019291640 hasConceptScore W2019291640C71924100 @default.
• W2019291640 hasConceptScore W2019291640C77411442 @default.
• W2019291640 hasConceptScore W2019291640C84393581 @default.
• W2019291640 hasIssue "2" @default.
• W2019291640 hasLocation W20192916401 @default.
• W2019291640 hasLocation W20192916402 @default.
• W2019291640 hasOpenAccess W2019291640 @default.
• W2019291640 hasPrimaryLocation W20192916401 @default.

• next