FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019291871> ?p ?o ?g. }

• W2019291871 endingPage "615" @default.
• W2019291871 startingPage "611" @default.
• W2019291871 abstract "Recurrence rates following conventional surgery for lentigo maligna (LM) are reported to be between 7% and 15%. However, the studies are few, contain small numbers of patients and have relatively short follow-up. The principle aim of this study was to determine the efficacy of conventional surgery for LM in a large unbiased sample of all LM presenting in a defined geographical area. All LM cases occurring in Leicestershire between 1987 and 1996 were identified. Data were gathered from case notes, general practitioners and the Office for National Statistics (for any mortality data) and patients were invited to attend for examination. There were 89 evaluable patients treated with primary excision, representing the largest reported series to date. There was a false positive rate for diagnostic biopsy for LM (when the correct diagnosis was lentigo maligna melanoma, LMM) of 5% (95% confidence interval, CI: 1% to 14%). The initial excision was histologically incomplete in 9% (4% to 17%) of cases. In completely excised lesions (n=81) the observed recurrence rate was 20% (CI: 12% to 30%) at a mean follow-up of 42 months, which is similar to previous reports. However, Kaplan-Meier analysis yielded an estimated probability of recurrence of 31% (CI: 19% to 50%); time to relapse was up to 66 months. The age and sex of the patient and the site of the lesion were not associated with outcome, but, surprisingly, smaller lesions were associated with incomplete excision and recurrence. Fifteen current lesions were excised with similar success rates: the incomplete re-excision rate was 7% (CI: 0.2% to 32%) and the recurrence rate was 31% (CI: 12% to 83%) at 28 months. The estimated rate of transformation to LMM after initial surgical treatment was 1.5% (CI: 0.3% to 8%), and LMM was not the cause of death in any patient. These recurrence rates following complete primary excision and re-excision following recurrence were high compared with general expectations, which is largely the result of the method of analysis and the long follow-up. The high rate calls into question the accuracy of the routine histological assessment of clearance. The development of LMM was rare following surgery." @default.
• W2019291871 created "2016-06-24" @default.
• W2019291871 creator A5022038771 @default.
• W2019291871 creator A5090557010 @default.
• W2019291871 date "2002-12-01" @default.
• W2019291871 modified "2023-10-16" @default.
• W2019291871 title "A follow-up study to investigate the efficacy of initial treatment of lentigo maligna with surgical excision" @default.
• W2019291871 cites W1936396249 @default.
• W2019291871 cites W1965652319 @default.
• W2019291871 cites W1973893735 @default.
• W2019291871 cites W1993693548 @default.
• W2019291871 cites W2015131775 @default.
• W2019291871 cites W2032930630 @default.
• W2019291871 cites W2056074903 @default.
• W2019291871 cites W2101464127 @default.
• W2019291871 cites W2166111863 @default.
• W2019291871 cites W3140436778 @default.
• W2019291871 cites W4301821761 @default.
• W2019291871 doi "https://doi.org/10.1054/bjps.2002.3967" @default.
• W2019291871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12550112" @default.
• W2019291871 hasPublicationYear "2002" @default.
• W2019291871 type Work @default.
• W2019291871 sameAs 2019291871 @default.
• W2019291871 citedByCount "137" @default.
• W2019291871 countsByYear W20192918712012 @default.
• W2019291871 countsByYear W20192918712013 @default.
• W2019291871 countsByYear W20192918712014 @default.
• W2019291871 countsByYear W20192918712015 @default.
• W2019291871 countsByYear W20192918712016 @default.
• W2019291871 countsByYear W20192918712017 @default.
• W2019291871 countsByYear W20192918712018 @default.
• W2019291871 countsByYear W20192918712019 @default.
• W2019291871 countsByYear W20192918712020 @default.
• W2019291871 countsByYear W20192918712021 @default.
• W2019291871 countsByYear W20192918712022 @default.
• W2019291871 countsByYear W20192918712023 @default.
• W2019291871 crossrefType "journal-article" @default.
• W2019291871 hasAuthorship W2019291871A5022038771 @default.
• W2019291871 hasAuthorship W2019291871A5090557010 @default.
• W2019291871 hasConcept C126322002 @default.
• W2019291871 hasConcept C126838900 @default.
• W2019291871 hasConcept C141071460 @default.
• W2019291871 hasConcept C2775934546 @default.
• W2019291871 hasConcept C2777393561 @default.
• W2019291871 hasConcept C2777658100 @default.
• W2019291871 hasConcept C2778303017 @default.
• W2019291871 hasConcept C2781156865 @default.
• W2019291871 hasConcept C44249647 @default.
• W2019291871 hasConcept C502942594 @default.
• W2019291871 hasConcept C71924100 @default.
• W2019291871 hasConceptScore W2019291871C126322002 @default.
• W2019291871 hasConceptScore W2019291871C126838900 @default.
• W2019291871 hasConceptScore W2019291871C141071460 @default.
• W2019291871 hasConceptScore W2019291871C2775934546 @default.
• W2019291871 hasConceptScore W2019291871C2777393561 @default.
• W2019291871 hasConceptScore W2019291871C2777658100 @default.
• W2019291871 hasConceptScore W2019291871C2778303017 @default.
• W2019291871 hasConceptScore W2019291871C2781156865 @default.
• W2019291871 hasConceptScore W2019291871C44249647 @default.
• W2019291871 hasConceptScore W2019291871C502942594 @default.
• W2019291871 hasConceptScore W2019291871C71924100 @default.
• W2019291871 hasIssue "8" @default.
• W2019291871 hasLocation W20192918711 @default.
• W2019291871 hasLocation W20192918712 @default.
• W2019291871 hasOpenAccess W2019291871 @default.
• W2019291871 hasPrimaryLocation W20192918711 @default.
• W2019291871 hasRelatedWork W1586374228 @default.
• W2019291871 hasRelatedWork W1781797981 @default.
• W2019291871 hasRelatedWork W2003938723 @default.
• W2019291871 hasRelatedWork W2047967234 @default.
• W2019291871 hasRelatedWork W2118496982 @default.
• W2019291871 hasRelatedWork W2364998975 @default.
• W2019291871 hasRelatedWork W2369162477 @default.
• W2019291871 hasRelatedWork W2439875401 @default.
• W2019291871 hasRelatedWork W4238867864 @default.
• W2019291871 hasRelatedWork W2525756941 @default.
• W2019291871 hasVolume "55" @default.
• W2019291871 isParatext "false" @default.
• W2019291871 isRetracted "false" @default.
• W2019291871 magId "2019291871" @default.
• W2019291871 workType "article" @default.