Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019295327> ?p ?o ?g. }
- W2019295327 endingPage "8" @default.
- W2019295327 startingPage "1" @default.
- W2019295327 abstract "We report a method of synthesis and optimization of amino-functionalized silica nanoparticles (SiNPs) and their in vitro evaluation as targeted delivery vehicles for the potential treatment of pancreatic cancer. SiNPs can efficiently encapsulate doxorubicin and can be attached to a targeting moiety such as anti-Claudin-4 (CLN4). The preferential uptake in pancreatic cancer cells, where CLN4 is overexpressed, of SiNPs when conjugated to CLN4 antibody (compared to nonconjugated SiNPs) was confirmed by confocal microscopy. SiNPs encapsulating doxorubicin had greater efficacy in MTT assays than free doxorubicin, and when conjugated to CLN4, the efficacy was dramatically increased (at 1 μ M). No apparent carrier toxicity was observed when void SiNPs were used. SiNPs carrying a chemotherapeutic drug have the potential to be used as a targeted therapy for lethal cancers, such as pancreatic cancer. Also, incorporation of fluorescent probes in these SiNPs creates the possibility of their use as an imaging probe for diagnostic purposes." @default.
- W2019295327 created "2016-06-24" @default.
- W2019295327 creator A5018861404 @default.
- W2019295327 creator A5020733118 @default.
- W2019295327 creator A5070873484 @default.
- W2019295327 date "2013-01-01" @default.
- W2019295327 modified "2023-10-05" @default.
- W2019295327 title "Amino-Functionalized Silica Nanoparticles: In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer" @default.
- W2019295327 cites W1548443253 @default.
- W2019295327 cites W1964951606 @default.
- W2019295327 cites W1985469984 @default.
- W2019295327 cites W1989195046 @default.
- W2019295327 cites W1993728532 @default.
- W2019295327 cites W1995833873 @default.
- W2019295327 cites W1998788310 @default.
- W2019295327 cites W2006986838 @default.
- W2019295327 cites W2012748063 @default.
- W2019295327 cites W2018762019 @default.
- W2019295327 cites W2019760663 @default.
- W2019295327 cites W2020499292 @default.
- W2019295327 cites W2032790167 @default.
- W2019295327 cites W2041708304 @default.
- W2019295327 cites W2057059824 @default.
- W2019295327 cites W2057256078 @default.
- W2019295327 cites W2059972525 @default.
- W2019295327 cites W2070517548 @default.
- W2019295327 cites W2073932571 @default.
- W2019295327 cites W2079967014 @default.
- W2019295327 cites W2082105104 @default.
- W2019295327 cites W2087020662 @default.
- W2019295327 cites W2087854516 @default.
- W2019295327 cites W2093755642 @default.
- W2019295327 cites W2099278062 @default.
- W2019295327 cites W2100240421 @default.
- W2019295327 cites W2110233014 @default.
- W2019295327 cites W2130931144 @default.
- W2019295327 cites W2143705915 @default.
- W2019295327 cites W2169850451 @default.
- W2019295327 cites W2185524839 @default.
- W2019295327 cites W2744383407 @default.
- W2019295327 cites W4249640893 @default.
- W2019295327 doi "https://doi.org/10.1155/2013/768724" @default.
- W2019295327 hasPublicationYear "2013" @default.
- W2019295327 type Work @default.
- W2019295327 sameAs 2019295327 @default.
- W2019295327 citedByCount "26" @default.
- W2019295327 countsByYear W20192953272013 @default.
- W2019295327 countsByYear W20192953272014 @default.
- W2019295327 countsByYear W20192953272015 @default.
- W2019295327 countsByYear W20192953272016 @default.
- W2019295327 countsByYear W20192953272017 @default.
- W2019295327 countsByYear W20192953272018 @default.
- W2019295327 countsByYear W20192953272019 @default.
- W2019295327 countsByYear W20192953272020 @default.
- W2019295327 countsByYear W20192953272021 @default.
- W2019295327 countsByYear W20192953272022 @default.
- W2019295327 countsByYear W20192953272023 @default.
- W2019295327 crossrefType "journal-article" @default.
- W2019295327 hasAuthorship W2019295327A5018861404 @default.
- W2019295327 hasAuthorship W2019295327A5020733118 @default.
- W2019295327 hasAuthorship W2019295327A5070873484 @default.
- W2019295327 hasBestOaLocation W20192953271 @default.
- W2019295327 hasConcept C112613896 @default.
- W2019295327 hasConcept C121608353 @default.
- W2019295327 hasConcept C12554922 @default.
- W2019295327 hasConcept C126322002 @default.
- W2019295327 hasConcept C155672457 @default.
- W2019295327 hasConcept C159985019 @default.
- W2019295327 hasConcept C171250308 @default.
- W2019295327 hasConcept C185592680 @default.
- W2019295327 hasConcept C192562407 @default.
- W2019295327 hasConcept C202751555 @default.
- W2019295327 hasConcept C2776694085 @default.
- W2019295327 hasConcept C2779178360 @default.
- W2019295327 hasConcept C2779820397 @default.
- W2019295327 hasConcept C2780210213 @default.
- W2019295327 hasConcept C2781230642 @default.
- W2019295327 hasConcept C2781303535 @default.
- W2019295327 hasConcept C2983331546 @default.
- W2019295327 hasConcept C502942594 @default.
- W2019295327 hasConcept C521977710 @default.
- W2019295327 hasConcept C55493867 @default.
- W2019295327 hasConcept C71924100 @default.
- W2019295327 hasConcept C86803240 @default.
- W2019295327 hasConcept C95444343 @default.
- W2019295327 hasConceptScore W2019295327C112613896 @default.
- W2019295327 hasConceptScore W2019295327C121608353 @default.
- W2019295327 hasConceptScore W2019295327C12554922 @default.
- W2019295327 hasConceptScore W2019295327C126322002 @default.
- W2019295327 hasConceptScore W2019295327C155672457 @default.
- W2019295327 hasConceptScore W2019295327C159985019 @default.
- W2019295327 hasConceptScore W2019295327C171250308 @default.
- W2019295327 hasConceptScore W2019295327C185592680 @default.
- W2019295327 hasConceptScore W2019295327C192562407 @default.
- W2019295327 hasConceptScore W2019295327C202751555 @default.
- W2019295327 hasConceptScore W2019295327C2776694085 @default.
- W2019295327 hasConceptScore W2019295327C2779178360 @default.
- W2019295327 hasConceptScore W2019295327C2779820397 @default.