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- W2019298345 endingPage "e110943" @default.
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- W2019298345 abstract "Humans are colonized by thousands of bacterial species, but it is difficult to assess the metabolic and pathogenic potential of the majority of these because they have yet to be cultured. Here, we characterize an uncultivated vaginal mycoplasma tightly associated with trichomoniasis that was previously known by its 16S rRNA sequence as “Mnola.” In this study, the mycoplasma was found almost exclusively in women infected with the sexually transmitted pathogen Trichomonas vaginalis, but rarely observed in women with no diagnosed disease. The genomes of four strains of this species were reconstructed using metagenome sequencing and assembly of DNA from four discrete mid-vaginal samples, one of which was obtained from a pregnant woman with trichomoniasis who delivered prematurely. These bacteria harbor several putative virulence factors and display unique metabolic strategies. Genes encoding proteins with high similarity to potential virulence factors include two collagenases, a hemolysin, an O-sialoglycoprotein endopeptidase and a feoB-type ferrous iron transport system. We propose the name “Candidatus Mycoplasma girerdii” for this potential new pathogen." @default.
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- W2019298345 date "2014-10-22" @default.
- W2019298345 modified "2023-10-01" @default.
- W2019298345 title "An Emerging Mycoplasma Associated with Trichomoniasis, Vaginal Infection and Disease" @default.
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- W2019298345 doi "https://doi.org/10.1371/journal.pone.0110943" @default.
- W2019298345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4206474" @default.
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