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• W2019298865 startingPage "194" @default.
• W2019298865 abstract "Enzyme immobilization on solid supports has been key to biotransformation development. Although technologies for immobilization have largely reached maturity, the resulting biocatalysts are not well understood mechanistically. One limitation is that their internal environment is usually inferred from external data. Therefore, biological consequences of the immobilization remain masked by physical effects of mass transfer, obstructing further development. Work reviewed herein shows that opto-chemical sensing performed directly within the solid support enables the biocatalyst's internal environment to be uncovered quantitatively and in real time. Non-invasive methods of intraparticle pH and O2 determination are presented, and their use as process analytical tools for development of heterogeneous biocatalysts is described. Method diversification to other analytes remains a challenging task for the future. Enzyme immobilization on solid supports has been key to biotransformation development. Although technologies for immobilization have largely reached maturity, the resulting biocatalysts are not well understood mechanistically. One limitation is that their internal environment is usually inferred from external data. Therefore, biological consequences of the immobilization remain masked by physical effects of mass transfer, obstructing further development. Work reviewed herein shows that opto-chemical sensing performed directly within the solid support enables the biocatalyst's internal environment to be uncovered quantitatively and in real time. Non-invasive methods of intraparticle pH and O2 determination are presented, and their use as process analytical tools for development of heterogeneous biocatalysts is described. Method diversification to other analytes remains a challenging task for the future." @default.
• W2019298865 created "2016-06-24" @default.
• W2019298865 creator A5051203357 @default.
• W2019298865 creator A5055224469 @default.
• W2019298865 creator A5070615900 @default.
• W2019298865 creator A5082698034 @default.
• W2019298865 date "2013-03-01" @default.
• W2019298865 modified "2023-10-15" @default.
• W2019298865 title "Shine a light on immobilized enzymes: real-time sensing in solid supported biocatalysts" @default.
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