FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019301183> ?p ?o ?g. }

• W2019301183 endingPage "239" @default.
• W2019301183 startingPage "229" @default.
• W2019301183 abstract "Obese women suffer from anovulation and infertility, which are driven by oxidative stress caused by increased levels of lipid peroxides and circulating oxidized low-density lipoprotein (oxLDL). OxLDL binds to lectin-like oxLDL receptor 1 (LOX-1), cluster of differentiation 36 (CD36), and toll-like receptor 4 (TLR4) and causes cell death in human granulosa cells (GCs). Our objective was to reveal whether treatment with antioxidants resveratrol (RES) and/or desferoxamine (DFO) protect GCs from oxLDL-induced damage. This basic research study was performed at the Institute of Anatomy and the Clinic of Reproductive Medicine. Patients were women undergoing in vitro fertilization therapy. GC cultures were treated with oxLDL alone or with RES or DFO under serum-free conditions for up to 36 hours. Dead cells were determined by propidium iodide uptake, cleaved caspase-3 expression, and electron microscopy. Mitosis was detected by Ki-67 immunostaining. LOX-1, TLR4, CD36, and heat-shock protein 60 were examined by Western blot. Measurement of oxidative stress markers (8-iso-prostaglandin F2α, advanced glycation end products, and protein carbonyl content) was conducted with ELISA kits. Different subtypes of human GCs exposed to RES or DFO were protected as evidenced by the lack of cell death, enhanced mitosis, induction of protective autophagy, reduction of oxidative stress markers, and reduced expression of LOX-1, TLR4, CD36, and heat-shock protein 60. Importantly, RES could restore steroid biosynthesis in cytokeratin-positive GCs, which exhibited significant induction of steroidogenic acute regulatory protein. RES and DFO exert a protective effect on human GCs. Thus, RES and DFO may help improve the treatment of obese women or polycystic ovarian syndrome patients undergoing in vitro fertilization therapy." @default.
• W2019301183 created "2016-06-24" @default.
• W2019301183 creator A5001074705 @default.
• W2019301183 creator A5007440202 @default.
• W2019301183 creator A5022920379 @default.
• W2019301183 creator A5038027244 @default.
• W2019301183 creator A5054886385 @default.
• W2019301183 creator A5083402534 @default.
• W2019301183 date "2014-01-01" @default.
• W2019301183 modified "2023-10-14" @default.
• W2019301183 title "Resveratrol and Desferoxamine Protect Human OxLDL-Treated Granulosa Cell Subtypes From Degeneration" @default.
• W2019301183 cites W1502393288 @default.
• W2019301183 cites W1626393855 @default.
• W2019301183 cites W1669871566 @default.
• W2019301183 cites W1966234811 @default.
• W2019301183 cites W1967964480 @default.
• W2019301183 cites W1969892925 @default.
• W2019301183 cites W1972153352 @default.
• W2019301183 cites W1972324826 @default.
• W2019301183 cites W1974208182 @default.
• W2019301183 cites W1976929342 @default.
• W2019301183 cites W1977079395 @default.
• W2019301183 cites W1983084250 @default.
• W2019301183 cites W1986962958 @default.
• W2019301183 cites W1991105254 @default.
• W2019301183 cites W1996354329 @default.
• W2019301183 cites W2006566278 @default.
• W2019301183 cites W2012960949 @default.
• W2019301183 cites W2016520821 @default.
• W2019301183 cites W2018274913 @default.
• W2019301183 cites W2018620079 @default.
• W2019301183 cites W2026956101 @default.
• W2019301183 cites W2038812560 @default.
• W2019301183 cites W2038899169 @default.
• W2019301183 cites W2046167249 @default.
• W2019301183 cites W2079383900 @default.
• W2019301183 cites W2094124280 @default.
• W2019301183 cites W2096380548 @default.
• W2019301183 cites W2104256886 @default.
• W2019301183 cites W2108353107 @default.
• W2019301183 cites W2110428682 @default.
• W2019301183 cites W2128594838 @default.
• W2019301183 cites W2144600435 @default.
• W2019301183 cites W2146390943 @default.
• W2019301183 cites W2152189545 @default.
• W2019301183 cites W2152667209 @default.
• W2019301183 cites W2154587590 @default.
• W2019301183 cites W2160875934 @default.
• W2019301183 cites W2163859237 @default.
• W2019301183 doi "https://doi.org/10.1210/jc.2013-2692" @default.
• W2019301183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24170104" @default.
• W2019301183 hasPublicationYear "2014" @default.
• W2019301183 type Work @default.
• W2019301183 sameAs 2019301183 @default.
• W2019301183 citedByCount "20" @default.
• W2019301183 countsByYear W20193011832014 @default.
• W2019301183 countsByYear W20193011832015 @default.
• W2019301183 countsByYear W20193011832016 @default.
• W2019301183 countsByYear W20193011832017 @default.
• W2019301183 countsByYear W20193011832018 @default.
• W2019301183 countsByYear W20193011832019 @default.
• W2019301183 countsByYear W20193011832020 @default.
• W2019301183 countsByYear W20193011832021 @default.
• W2019301183 countsByYear W20193011832022 @default.
• W2019301183 countsByYear W20193011832023 @default.
• W2019301183 crossrefType "journal-article" @default.
• W2019301183 hasAuthorship W2019301183A5001074705 @default.
• W2019301183 hasAuthorship W2019301183A5007440202 @default.
• W2019301183 hasAuthorship W2019301183A5022920379 @default.
• W2019301183 hasAuthorship W2019301183A5038027244 @default.
• W2019301183 hasAuthorship W2019301183A5054886385 @default.
• W2019301183 hasAuthorship W2019301183A5083402534 @default.
• W2019301183 hasBestOaLocation W20193011831 @default.
• W2019301183 hasConcept C104317684 @default.
• W2019301183 hasConcept C126322002 @default.
• W2019301183 hasConcept C134018914 @default.
• W2019301183 hasConcept C170493617 @default.
• W2019301183 hasConcept C185592680 @default.
• W2019301183 hasConcept C190283241 @default.
• W2019301183 hasConcept C205260736 @default.
• W2019301183 hasConcept C2775934118 @default.
• W2019301183 hasConcept C2776151105 @default.
• W2019301183 hasConcept C2779828298 @default.
• W2019301183 hasConcept C31573885 @default.
• W2019301183 hasConcept C55493867 @default.
• W2019301183 hasConcept C71924100 @default.
• W2019301183 hasConcept C86803240 @default.
• W2019301183 hasConceptScore W2019301183C104317684 @default.
• W2019301183 hasConceptScore W2019301183C126322002 @default.
• W2019301183 hasConceptScore W2019301183C134018914 @default.
• W2019301183 hasConceptScore W2019301183C170493617 @default.
• W2019301183 hasConceptScore W2019301183C185592680 @default.
• W2019301183 hasConceptScore W2019301183C190283241 @default.
• W2019301183 hasConceptScore W2019301183C205260736 @default.
• W2019301183 hasConceptScore W2019301183C2775934118 @default.
• W2019301183 hasConceptScore W2019301183C2776151105 @default.
• W2019301183 hasConceptScore W2019301183C2779828298 @default.
• W2019301183 hasConceptScore W2019301183C31573885 @default.

• next