FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019302271> ?p ?o ?g. }

• W2019302271 endingPage "117" @default.
• W2019302271 startingPage "108" @default.
• W2019302271 abstract "Trypanosomes are protozoan parasites responsible for recalcitrant infectious diseases such as Sleeping sickness and Chagas disease in Africa and America, respectively. Their complex life-cycles are accompanied by alternation of forms specific of the insect vectors and vertebrate hosts, each with different metabolic and structural requirements. Unlike most other eukaryotes, these single-cell microorganisms seem to control the expression of protein-coding genes mostly by mRNA degradation, silencing and translation efficiency. Recent evidence showed that genuine cytoplasmic Stress Granules are formed as a response to heat stress in Trypanosoma brucei, basically formed by stalled translation initiation complexes on mRNA. On the other hand, Processing bodies (P bodies) are constitutive components of cytoplasmic mRNA metabolism in trypanosomes, which could have an important role in translational repression. During physiological starvation conditions in trypanosomes, components from P bodies fuse with other ribonucleoprotein complexes to form mRNA granules, where transcripts are stored and protected from degradation in a quiescent state. Other novel types of foci with unknown function that are related to RNA metabolism can be found in these parasites, namely heat-induced granules containing the 5' to 3' exoribonuclease XRNA, and starvation-induced granules containing transfer RNA halves. Thus, trypanosomes make use of non-membranous structures as a strategy to compartmentalize ribonucleoprotein complexes in the cytoplasm, aiding to cope with stressful situations avoiding mRNA translation or degradation. The relevance of stressinduced foci in trypanosomes has yet to be scored, although recent evidence suggests that these cytoplasmic organelles are required for survival under adverse growing conditions. Keywords: Gene expression, P bodies, post-transcriptional, RNA granules, RNA-binding protein, stress granules, trypanosoma, Trypanosoma brucei, T. cruzi, PROCESSING BODIES, Met-tRNA" @default.
• W2019302271 created "2016-06-24" @default.
• W2019302271 creator A5075675811 @default.
• W2019302271 date "2011-05-01" @default.
• W2019302271 modified "2023-10-18" @default.
• W2019302271 title "RNA Granules Living a Post-Transcriptional Life: the Trypanosome's Case" @default.
• W2019302271 cites W1503077302 @default.
• W2019302271 cites W1536529218 @default.
• W2019302271 cites W181468314 @default.
• W2019302271 cites W185783770 @default.
• W2019302271 cites W1919951605 @default.
• W2019302271 cites W1933230950 @default.
• W2019302271 cites W1964628768 @default.
• W2019302271 cites W1964869212 @default.
• W2019302271 cites W1970022594 @default.
• W2019302271 cites W1985581648 @default.
• W2019302271 cites W1990584803 @default.
• W2019302271 cites W1991923259 @default.
• W2019302271 cites W1992935306 @default.
• W2019302271 cites W1993180746 @default.
• W2019302271 cites W2002772339 @default.
• W2019302271 cites W2002928823 @default.
• W2019302271 cites W2003783312 @default.
• W2019302271 cites W2003911773 @default.
• W2019302271 cites W2007085897 @default.
• W2019302271 cites W2009994916 @default.
• W2019302271 cites W2010654081 @default.
• W2019302271 cites W2014028277 @default.
• W2019302271 cites W2014802525 @default.
• W2019302271 cites W2017184218 @default.
• W2019302271 cites W2022862766 @default.
• W2019302271 cites W2024123477 @default.
• W2019302271 cites W2024536332 @default.
• W2019302271 cites W2025007214 @default.
• W2019302271 cites W2027023374 @default.
• W2019302271 cites W2028356785 @default.
• W2019302271 cites W2034325006 @default.
• W2019302271 cites W2034413541 @default.
• W2019302271 cites W2034774838 @default.
• W2019302271 cites W2038049104 @default.
• W2019302271 cites W2039278923 @default.
• W2019302271 cites W2040640278 @default.
• W2019302271 cites W2042188385 @default.
• W2019302271 cites W2044821390 @default.
• W2019302271 cites W2049311171 @default.
• W2019302271 cites W2050083559 @default.
• W2019302271 cites W2055321146 @default.
• W2019302271 cites W2058982772 @default.
• W2019302271 cites W2061276931 @default.
• W2019302271 cites W2065677302 @default.
• W2019302271 cites W2071043257 @default.
• W2019302271 cites W2073583408 @default.
• W2019302271 cites W2076495609 @default.
• W2019302271 cites W2077829198 @default.
• W2019302271 cites W2079051847 @default.
• W2019302271 cites W2084119410 @default.
• W2019302271 cites W2088156779 @default.
• W2019302271 cites W2088366327 @default.
• W2019302271 cites W2096948009 @default.
• W2019302271 cites W2103816714 @default.
• W2019302271 cites W2105141777 @default.
• W2019302271 cites W2109140791 @default.
• W2019302271 cites W2111874641 @default.
• W2019302271 cites W2111933838 @default.
• W2019302271 cites W2112523914 @default.
• W2019302271 cites W2112765717 @default.
• W2019302271 cites W2114175350 @default.
• W2019302271 cites W2115027952 @default.
• W2019302271 cites W2116592258 @default.
• W2019302271 cites W2116714498 @default.
• W2019302271 cites W2118510242 @default.
• W2019302271 cites W2120194124 @default.
• W2019302271 cites W2121570734 @default.
• W2019302271 cites W2124769246 @default.
• W2019302271 cites W2128398569 @default.
• W2019302271 cites W2129201076 @default.
• W2019302271 cites W2131623079 @default.
• W2019302271 cites W2134530067 @default.
• W2019302271 cites W2136615690 @default.
• W2019302271 cites W2141707748 @default.
• W2019302271 cites W2141827783 @default.
• W2019302271 cites W2146981677 @default.
• W2019302271 cites W2147997023 @default.
• W2019302271 cites W2148282376 @default.
• W2019302271 cites W2148892576 @default.
• W2019302271 cites W2149403492 @default.
• W2019302271 cites W2151265156 @default.
• W2019302271 cites W2157974457 @default.
• W2019302271 cites W2161732896 @default.
• W2019302271 cites W2162391016 @default.
• W2019302271 cites W2164419864 @default.
• W2019302271 cites W2164760302 @default.
• W2019302271 cites W2166459128 @default.
• W2019302271 cites W2168799765 @default.
• W2019302271 cites W2168806010 @default.
• W2019302271 doi "https://doi.org/10.2174/2212796811105020108" @default.
• W2019302271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3179377" @default.
• W2019302271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21949551" @default.

• next