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- W2019303497 abstract "Mitochondria and the nucleus are key features that distinguish eukaryotic cells from prokaryotic cells. Mitochondria originated from a bacterium that was endosymbiotically taken up by another cell more than a billion years ago. Subsequently, most mitochondrial genes were transferred and integrated into the host cell's genome, making the evolution of pathways for specific import of mitochondrial proteins necessary. The mitochondrial protein translocation machineries are composed of numerous subunits. Interestingly, many of these subunits are at least in part derived from bacterial proteins, although only few of them functioned in bacterial protein translocation. We propose that the primitive α-proteobacterium, which was once taken up by the eukaryote ancestor cell, contained a number of components that were utilized for the generation of mitochondrial import machineries. Many bacterial components of seemingly unrelated pathways were integrated to form the modern cooperative mitochondria-specific protein translocation system." @default.
- W2019303497 created "2016-06-24" @default.
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- W2019303497 creator A5016591234 @default.
- W2019303497 creator A5020320687 @default.
- W2019303497 creator A5068752218 @default.
- W2019303497 date "2009-06-01" @default.
- W2019303497 modified "2023-10-16" @default.
- W2019303497 title "Evolution of mitochondrial protein biogenesis" @default.
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- W2019303497 doi "https://doi.org/10.1016/j.bbagen.2009.04.004" @default.
- W2019303497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19362582" @default.
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