Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019307739> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2019307739 abstract "The objective of the investigation was to optimize the iontophoresis process parameters of lisinopril (LSP) by 3 x 3 factorial design, Box-Behnken statistical design. LSP is an ideal candidate for iontophoretic delivery to avoid the incomplete absorption problem associated after its oral administration. Independent variables selected were current (X(1)), salt (sodium chloride) concentration (X(2)) and medium/pH (X(3)). The dependent variables studied were amount of LSP permeated in 4 h (Y(1): Q(4)), 24 h (Y(2): Q(24)) and lag time (Y(3)). Mathematical equations and response surface plots were used to relate the dependent and independent variables. The regression equation generated for the iontophoretic permeation was Y(1) = 1.98 + 1.23X(1) - 0.49X(2) + 0.025X(3) - 0.49X(1)X(2) + 0.040X(1)X(3) - 0.010X(2)X(3) + 0.58X(1)(2) - 0.17X(2)(2) - 0.18X(3)(2); Y(2) = 7.28 + 3.32X(1) - 1.52X(2) + 0.22X(3) - 1.30X(1)X(2) + 0.49X(1)X(3) - 0.090X(2)X(3) + 0.79X(1)(2) - 0.62X(2)(2) - 0.33X(3)(2) and Y(3) = 0.60 + 0.0038X(1) + 0.12X(2) - 0.011X(3) + 0.005X(1)X(2) - 0.018X(1)X(3) - 0.015X(2)X(3) - 0.00075X(1)(2) + 0.017X(2)(2) - 0.11X(3)(2). The statistical validity of the polynomials was established and optimized process parameters were selected by feasibility and grid search. Validation of the optimization study with 8 confirmatory runs indicated high degree of prognostic ability of response surface methodology. The use of Box-Behnken design approach helped in identifying the critical process parameters in the iontophoretic delivery of lisinopril." @default.
- W2019307739 created "2016-06-24" @default.
- W2019307739 creator A5011286649 @default.
- W2019307739 creator A5033022937 @default.
- W2019307739 creator A5058157017 @default.
- W2019307739 creator A5066543696 @default.
- W2019307739 creator A5079055334 @default.
- W2019307739 date "2009-07-09" @default.
- W2019307739 modified "2023-09-26" @default.
- W2019307739 title "Iontophoretic delivery of lisinopril: Optimization of process variables by Box-Behnken statistical design" @default.
- W2019307739 cites W13604522 @default.
- W2019307739 cites W1495711235 @default.
- W2019307739 cites W1709109739 @default.
- W2019307739 cites W1965258535 @default.
- W2019307739 cites W1974637913 @default.
- W2019307739 cites W1976904023 @default.
- W2019307739 cites W1980895592 @default.
- W2019307739 cites W1987558091 @default.
- W2019307739 cites W1994312127 @default.
- W2019307739 cites W1998162402 @default.
- W2019307739 cites W2002671537 @default.
- W2019307739 cites W2007475889 @default.
- W2019307739 cites W2016262854 @default.
- W2019307739 cites W2021690910 @default.
- W2019307739 cites W2022172016 @default.
- W2019307739 cites W2030781379 @default.
- W2019307739 cites W2048694743 @default.
- W2019307739 cites W2086713061 @default.
- W2019307739 cites W2090783538 @default.
- W2019307739 cites W2094327592 @default.
- W2019307739 cites W2102397750 @default.
- W2019307739 cites W2134083404 @default.
- W2019307739 cites W2140663863 @default.
- W2019307739 cites W2155751766 @default.
- W2019307739 cites W2273084465 @default.
- W2019307739 cites W2518001066 @default.
- W2019307739 doi "https://doi.org/10.1080/10837450903085418" @default.
- W2019307739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19586491" @default.
- W2019307739 hasPublicationYear "2009" @default.
- W2019307739 type Work @default.
- W2019307739 sameAs 2019307739 @default.
- W2019307739 citedByCount "1" @default.
- W2019307739 countsByYear W20193077392012 @default.
- W2019307739 crossrefType "journal-article" @default.
- W2019307739 hasAuthorship W2019307739A5011286649 @default.
- W2019307739 hasAuthorship W2019307739A5033022937 @default.
- W2019307739 hasAuthorship W2019307739A5058157017 @default.
- W2019307739 hasAuthorship W2019307739A5066543696 @default.
- W2019307739 hasAuthorship W2019307739A5079055334 @default.
- W2019307739 hasConcept C105795698 @default.
- W2019307739 hasConcept C125287762 @default.
- W2019307739 hasConcept C126838900 @default.
- W2019307739 hasConcept C150077022 @default.
- W2019307739 hasConcept C159985019 @default.
- W2019307739 hasConcept C169222746 @default.
- W2019307739 hasConcept C170295934 @default.
- W2019307739 hasConcept C183529106 @default.
- W2019307739 hasConcept C185592680 @default.
- W2019307739 hasConcept C186060115 @default.
- W2019307739 hasConcept C192562407 @default.
- W2019307739 hasConcept C27016395 @default.
- W2019307739 hasConcept C2777880890 @default.
- W2019307739 hasConcept C2993377847 @default.
- W2019307739 hasConcept C33923547 @default.
- W2019307739 hasConcept C43617362 @default.
- W2019307739 hasConcept C71924100 @default.
- W2019307739 hasConcept C84393581 @default.
- W2019307739 hasConcept C86803240 @default.
- W2019307739 hasConceptScore W2019307739C105795698 @default.
- W2019307739 hasConceptScore W2019307739C125287762 @default.
- W2019307739 hasConceptScore W2019307739C126838900 @default.
- W2019307739 hasConceptScore W2019307739C150077022 @default.
- W2019307739 hasConceptScore W2019307739C159985019 @default.
- W2019307739 hasConceptScore W2019307739C169222746 @default.
- W2019307739 hasConceptScore W2019307739C170295934 @default.
- W2019307739 hasConceptScore W2019307739C183529106 @default.
- W2019307739 hasConceptScore W2019307739C185592680 @default.
- W2019307739 hasConceptScore W2019307739C186060115 @default.
- W2019307739 hasConceptScore W2019307739C192562407 @default.
- W2019307739 hasConceptScore W2019307739C27016395 @default.
- W2019307739 hasConceptScore W2019307739C2777880890 @default.
- W2019307739 hasConceptScore W2019307739C2993377847 @default.
- W2019307739 hasConceptScore W2019307739C33923547 @default.
- W2019307739 hasConceptScore W2019307739C43617362 @default.
- W2019307739 hasConceptScore W2019307739C71924100 @default.
- W2019307739 hasConceptScore W2019307739C84393581 @default.
- W2019307739 hasConceptScore W2019307739C86803240 @default.
- W2019307739 hasLocation W20193077391 @default.
- W2019307739 hasLocation W20193077392 @default.
- W2019307739 hasOpenAccess W2019307739 @default.
- W2019307739 hasPrimaryLocation W20193077391 @default.
- W2019307739 isParatext "false" @default.
- W2019307739 isRetracted "false" @default.
- W2019307739 magId "2019307739" @default.
- W2019307739 workType "article" @default.