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• W2019315378 abstract "Purpose . To assess the prognostic role of 14F7 Mab immunoreactivity, against N-Glycolyl GM3 ganglioside, in patients with colon cancer (CC) and to evaluate the relationship between its expression and clinicopathological features. Methods . Paraffin-embedded specimens were retrospectively collected from 50 patients with CC operated between 2004 and 2008. 14F7 Mab staining was determined by immunohistochemistry technique and its relation with survival and clinicopathologic features was evaluated. Results . The reactivity of 14F7 Mab was detected in all cases. Most cases had high level of immunostaining (70%) that showed statistical correlation with TNM stage<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.025</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. In univariate survival analysis, level of 14F7 Mab immunoreactivity<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0078</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>, TNM Stage<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0007</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>and lymphovascular invasion<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mo stretchy=false>(</mml:mo><mml:mn>0.027</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>were significant prognostic factors for overall survival. Among these variables, level of 14F7 Mab immunoreactivity<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi> </mml:mi><mml:mo stretchy=false>(</mml:mo><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>268</mml:mn><mml:mo>;</mml:mo><mml:mi> </mml:mi><mml:mn>95</mml:mn><mml:mi>%</mml:mi><mml:mtext> CI </mml:mtext><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>078</mml:mn><mml:mtext>–</mml:mtext><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>920</mml:mn><mml:mo>;</mml:mo><mml:mi> </mml:mi><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>036</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>and TNM stage<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mo stretchy=false>(</mml:mo><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>249</mml:mn><mml:mo>;</mml:mo><mml:mi> </mml:mi><mml:mn>95</mml:mn><mml:mi>%</mml:mi><mml:mtext> CI </mml:mtext><mml:mtext> </mml:mtext><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>066</mml:mn><mml:mtext>–</mml:mtext><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:mn>932</mml:mn><mml:mo>;</mml:mo><mml:mi> </mml:mi><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.039</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>were independent prognostic factors on multivariate analysis. Conclusions . This study is the first approach on the prognostic significance of 14F7 Mab immunoreactivity in patients with colon adenocarcinoma and this assessment might be used in the prognostic estimate of CC, although further studies will be required to validate these findings." @default.
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• W2019315378 date "2014-01-01" @default.
• W2019315378 modified "2023-09-27" @default.
• W2019315378 title "Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer" @default.
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• W2019315378 doi "https://doi.org/10.1155/2014/482301" @default.
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