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• W2019323104 abstract "C-type lectin receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. Upon ligand binding, CLRs induce a variety of cellular responses, such as respiratory burst, production of cytokines and chemokines, and consequently shaping the adaptive immune responses. Recent frontier studies have demonstrated that CLRs play a significant role in development of anti-inflammatory immune responses and maintenance of host immune-homeostasis. In this review we describe the major CLRs involved in production of IL-10 by immune-related cells and functional maturation of regulatory T cells. In addition, we discuss the potential role of CLRs signaling in regulating intestinal immune-homeostasis and inflammation. Further understanding of the precise role for these receptors on immunoregulatory cells will provide unexpected opportunities for developing new therapies for inflammatory diseases." @default.
• W2019323104 created "2016-06-24" @default.
• W2019323104 creator A5053027137 @default.
• W2019323104 creator A5060130752 @default.
• W2019323104 creator A5088257762 @default.
• W2019323104 date "2013-07-01" @default.
• W2019323104 modified "2023-10-16" @default.
• W2019323104 title "The role of C-type lectin receptors in immune homeostasis" @default.
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• W2019323104 doi "https://doi.org/10.1016/j.intimp.2013.04.013" @default.
• W2019323104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23623943" @default.
• W2019323104 hasPublicationYear "2013" @default.
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