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• W2019323687 abstract "Natural killer T cells (NKT cells) are effector cells, but also regulator of immune response, which either promote or suppress immune response through production of different cytokines. However, the subsets of NKT cells with definite phenotype and regulatory function need to be further identified. Furthermore, the mechanisms for NKT cells to regulate immune response remain to be fully elucidated. Here we identified CD11b+ invariant NKT (CD11b+ iNKT) cells as a new subset of regulatory NKT cells in mouse models with infection. αGalCer:CD1d complex+TCRβ+NK1.1+ NKT cells could be categorized to CD11b+ and CD11b− subsets. NKT cells are enriched in liver. During Listeria monocytogenes infection, hepatic CD11b+ iNKT cells were significantly induced and expanded, with peak expansion on day 8. CD11b+ iNKT cells were also expanded significantly in spleen and mesenteric lymph nodes. As compared to CD11b− iNKT cells, CD11b+ iNKT cells expressed higher levels of CD27, FasL, B7H1, CD69, and particularly higher level of membrane-bound TGF-β1 (mTGF-β1), but produced less IFN-γ, IL-4, IL-10 and TGF-β1. Hepatic CD11b+ iNKT cells suppressed antigen-nonspecific and OVA-specific CD4 and CD8 T cell proliferation through mTGF-β1 both in vitro and in vivo, meanwhile, they did not interfere with activation of CD4 T cells and cytotoxicity of the activated CD8 T cells. Thus, we have identified a new subset of pathogen-expanded CD11b+ invariant NKT cells which can feedback inhibit T cell response through cell-to-cell contact via cell surface (membrane-bound) TGF-β1, especially at the late stage of immune response against infection. CD11b+ regulatory iNKT cells may contribute to protect host from pathological injure by preventing immune overactivation." @default.
• W2019323687 created "2016-06-24" @default.
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• W2019323687 date "2015-04-01" @default.
• W2019323687 modified "2023-10-16" @default.
• W2019323687 title "Pathogen-expanded CD11b+ invariant NKT cells feedback inhibit T cell proliferation via membrane-bound TGF-β1" @default.
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• W2019323687 doi "https://doi.org/10.1016/j.jaut.2014.12.006" @default.
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