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- W2019324516 abstract "In recent years phosphodiesterase V acts as an attractive target for cardiovascular drug design and QSAR techniques are helpful for the optimization of structural requirements for designing novel compounds. The present communication deals with 3D-QSAR analysis of 1-(2-ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as phosphodiesterase V inhibitors. The multiple linear regression analysis and kNN-MFA analysis were carried out on 33 reported 1-(2-ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines in Vlife MDS 3.5. The substitution of electron withdrawing groups in pyrazole ring and sterically less bulkier groups is important for the phosphodiesterase V inhibition indicated by both QSAR analyses. The two different QSAR models are generated by using two different principles, both the models are showing similar results which indicate that this kNN-MFA technique can be utilized for cross validation of the results of multiple linear regression studies." @default.
- W2019324516 created "2016-06-24" @default.
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- W2019324516 date "2015-05-01" @default.
- W2019324516 modified "2023-10-16" @default.
- W2019324516 title "3D QSAR, pharmacophore indentification studies on series of 1-(2-ethoxyethyl)-1H-pyrazolo [4,3-d]pyrimidines as phosphodiesterase V inhibitors" @default.
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- W2019324516 doi "https://doi.org/10.1016/j.jscs.2012.02.008" @default.
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