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• W2019336823 abstract "Very recently we proposed that hyperactivity of endothelial Ca2+/cGMP signaling under hyperglycemic conditions is due to superoxide anion (O2−) release. The present study was designed to investigate changes in endothelial glutathione (GSH) levels in response to high d-glucose and possible prevention of the high-d-glucose-initiated changes in Ca2+/cGMP signal by antioxidants. Under hyperglycemic conditions, GSH content increased by 29% within 4 h. Co-incubation with 10 mM GSH during high-d-glucose treatment normalized the Ca2+/cGMP response associated with an increase in GSH content by 222%. Vitamin C (250 μM) markedly diminished the high-d-glucose-mediated hyperreactivity of endothelial Ca2+ entry (by 40%) and Ca2+ release (by 52%). Similar to GSH, co-incubation with vitamin E (α-tocopherol; 50 μg/ml) and probucol (50 μM) completely prevented the high-d-glucose-inititiated hyperreactivity of the endothelial Ca2+/cGMP response. Vitamin E, probucol, GSH and vitamin C diminished the high-d-glucose-mediated O2− release by 78, 65, 89 and 46%, respectively. These data suggest that antioxidants prevent high-d-glucose-initiated changes in endothelial Ca2+/cGMP response by scavenging the overshoot of O2−. © 1997 Elsevier Science B.V. All rights reserved." @default.
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• W2019336823 date "1997-03-01" @default.
• W2019336823 modified "2023-10-14" @default.
• W2019336823 title "Antioxidants prevent high-d-glucose-enhanced endothelial Ca2+/cGMP response by scavenging superoxide anions" @default.
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• W2019336823 doi "https://doi.org/10.1016/s0014-2999(96)00989-2" @default.
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