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• W2019348599 abstract "LRPPRC (also called LRP130) is an RNA-binding pentatricopeptide repeat protein. LRPPRC has been recognized as a mitochondrial protein, but has also been shown to regulate nuclear gene transcription and to bind specific RNA molecules in both the nucleus and the cytoplasm. We here present a bioinformatic analysis of the LRPPRC primary sequence, which reveals that orthologs to the LRPPRC gene are restricted to metazoan cells and that all of the corresponding proteins contain mitochondrial targeting signals. To address the subcellular localization further, we have carefully analyzed LRPPRC in mammalian cells and identified a single isoform that is exclusively localized to mitochondria. The LRPPRC protein is imported to the mitochondrial matrix and its mitochondrial targeting sequence is cleaved upon entry." @default.
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• W2019348599 date "2010-08-01" @default.
• W2019348599 modified "2023-10-01" @default.
• W2019348599 title "LRPPRC is a mitochondrial matrix protein that is conserved in metazoans" @default.
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• W2019348599 doi "https://doi.org/10.1016/j.bbrc.2010.07.019" @default.
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