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- W2019357948 abstract "Peroxisome proliferator-activated receptor γ (PPARγ) is expressed in several human tumors including gastric, lung, colon, prostate and breast. However, the role of PPARγ signals in leukemia is still unclear. The aim of this study is to evaluate the ability of 15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> (15dPGJ<sub>2</sub>), that is a ligand for PPARγ, on proliferation of human leukemia cell line U937. 15dPGJ<sub>2</sub> at 5 µmol/l stimulated the proliferation. In contrast, 15dPGJ<sub>2</sub> at concentrations of >10 µmol/l inhibited the proliferation through the induction of apoptosis. PGD<sub>2</sub>, PGJ<sub>2</sub> and Δ<sup>12</sup>-PGJ<sub>2</sub> (ΔPGJ<sub>2</sub>), those are precursors of 15dPGJ<sub>2</sub>, had similarly proliferative effects, whereas they showed antiproliferative effects at high concentrations. FACScan analysis revealed that PGD<sub>2</sub> at 5 µmol/l, PGJ<sub>2</sub> at 1 µmol/l, ΔPGJ<sub>2</sub> at 1 µmol/l and 15dPGJ<sub>2</sub> at 5 µmol/l, all accelerated cell cycle progression. Immunoblotting analysis revealed that PGD<sub>2</sub> at 5 µmol/l and 15dPGJ<sub>2</sub> at 5 µmol/l inhibited the expression of phospho-p38, phospho-MKK3/MKK6 and phospho-ATF-2, and the expression of Cdk inhibitors including p18, p27. In contrast, PGJ<sub>2</sub> at 1 µmol/l and ΔPGJ<sub>2</sub> at 1 µmol/l did not affect the expression of them. These results suggest that 15dPGJ<sub>2</sub> and PGD<sub>2</sub> may, through inactivation of the p38 MAPK pathway, inhibit the expression of Cdk inhibitors, leading to acceleration of proliferation." @default.
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- W2019357948 title "Induction of Proliferation by 15-Deoxy-Δ<sup>12,14</sup>-Prostaglandin J<sub>2</sub> and the Precursors in Monocytic Leukemia U937" @default.
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- W2019357948 doi "https://doi.org/10.1159/000078084" @default.
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