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- W2019364039 abstract "Nine new alpha-methylene-gamma-butyrolactones were synthesized by the Reformatsky condensation of ethyl alpha-bromomethylacrylate with ketones, aldehydes, and an epoxide. A unique spirobutyrolactone class was prepared by reaction of the zinc alkyl derivative and N-methylisatins. The compounds were evaluated against L-1210 and P-388 leukemia and the 9KB carcinoma of the nasopharynx. They also were screened in a microbiocidal and an antifungal assay. The spiro methylene lactone of 5-iodo-N-methylisatin displayed activity in the P-388, 9KB, and antifungal screens." @default.
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- W2019364039 date "1981-01-01" @default.
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- W2019364039 title "Synthesis and Antibacterial and Anticancer Evaluations of α-Methylene-γ-butyrolactones" @default.
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- W2019364039 doi "https://doi.org/10.1002/jps.2600700117" @default.
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