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- W2019380023 abstract "To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3−(CD56+or CD16+) ratio (25.2% ± 6.8% vs 11.1% ± 7.0%), but an inverted CD3+CD8−CD3+CD8+ ratio (0.5 vs 1.8) and a minimal amount of B cells (3.3% ± 3.1%). TcR γδ+ T cells accounted for a minor proportion (7.8% ± 5.1%) in endometrium. The proportions of TcR αβ+ (85.0% ± 6.6%) and CD3+CD56+ (7.4% ± 4.4%) endometrial T lymphocytes were found significantly different from those in peripheral blood (89.1% ± 5.6% and 3.8% ± 3.4%, respectively). As the endometrium proceeded from proliferative phase to luteal phase, the proportion of CD3+CD8+ T cells in peripheral blood increased from 35.6% ± 6.9% to 41.3% ± 8.4% and CD3+CD8− T cells decreased from 64.4% ± 6.9% to 58.7% ± 8.4%. The endometrial T cells expressed high levels of CD69 (84.1% ± 18.9%) and DR (75.9% ± 9.7%), but rarely expressed CD25 (7.0% ± 5.4%) and CD71 (2.8% ± 1.8%). The patterns of expression of these activation markers were similar in both proliferative and luteal phases. Our observations suggest that endometrial T lymphocytes are in a state of recent and persistent activation. Lymphocytes expressing the NK cell markers (CD56 or CD16) and CD8+ accounted for a significant proportion, suggesting that they may play important roles in local defense. Human Immunology 42, 227–232 (1995)" @default.
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- W2019380023 date "1995-03-01" @default.
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- W2019380023 title "Increased expressions of CD69 and HLA-DR but not of CD25 or CD71 on endometrial T lymphocytes of nonpregnant women" @default.
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- W2019380023 doi "https://doi.org/10.1016/0198-8859(94)00105-y" @default.
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