FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019392590> ?p ?o ?g. }

• W2019392590 endingPage "68" @default.
• W2019392590 startingPage "66" @default.
• W2019392590 abstract "Aging study requires aging markers to measure the degree of aging process. The aging markers such as senescence associated-β-galactosidase (SA-β-gal), lipofuscin, telomere, p53 and p16 have been known in aging study until now. Therefore, we investigated the role of genes and proteins related to aging in young, senescent and H2O2-induced old cells to develop a novel aging marker involved in aging mechanism. After cellular aging was compared in young, senescent and H2O2-induced old cells using SA-β-galactosidase staining assay, the expression level of genes and proteins in senescent and H2O2-induced old cells were compared and analyzed with those of young cells using RT-PCR, western blot and immunofluorescence staining. First of all, the senescent cells and the cells aged by H2O2 showed higher level of SA-β-galactosidase staining than young cells. In particular, the expression level of IGFBP-3 was decreased in senescent and H2O2-induced old cells compared with young cells. Moreover, the senescent and H2O2-induced old cells showed higher expression levels of p-PI3K, Akt-1, p-mTOR, p-FoxO1 and FoxO1 than young cells. Furthermore, the expression levels of p300, Ac-p53, p53, p-p21 and p16 were significantly increased in senescent and H2O2-induced cells compared to young cells. However, the expression level of SIRT-1 was decreased in senescent and H2O2-induced old cells compared to young cells. In conclusion, IGFBP-3 up-regulates PI3K/Akt/mTOR signaling pathway and down-regulates autophagy during cell aging. These results suggest that IGFBP-3 could play a key role in aging study as an important aging marker." @default.
• W2019392590 created "2016-06-24" @default.
• W2019392590 creator A5012837780 @default.
• W2019392590 creator A5050346471 @default.
• W2019392590 creator A5056220797 @default.
• W2019392590 creator A5087490208 @default.
• W2019392590 date "2009-01-01" @default.
• W2019392590 modified "2023-10-03" @default.
• W2019392590 title "Medicina cardiovascular traslacional. Ahora o nunca" @default.
• W2019392590 cites W1978623890 @default.
• W2019392590 cites W1979604620 @default.
• W2019392590 cites W1984243363 @default.
• W2019392590 cites W1987141813 @default.
• W2019392590 cites W1991776156 @default.
• W2019392590 cites W1999344992 @default.
• W2019392590 cites W2000719872 @default.
• W2019392590 cites W2002612700 @default.
• W2019392590 cites W2003196698 @default.
• W2019392590 cites W2009210241 @default.
• W2019392590 cites W2009969391 @default.
• W2019392590 cites W2016017240 @default.
• W2019392590 cites W2038250952 @default.
• W2019392590 cites W2048835478 @default.
• W2019392590 cites W2064700737 @default.
• W2019392590 cites W2074976755 @default.
• W2019392590 cites W2075567703 @default.
• W2019392590 cites W2083289225 @default.
• W2019392590 cites W2101975460 @default.
• W2019392590 cites W2152158712 @default.
• W2019392590 doi "https://doi.org/10.1016/s0300-8932(09)70022-3" @default.
• W2019392590 hasPublicationYear "2009" @default.
• W2019392590 type Work @default.
• W2019392590 sameAs 2019392590 @default.
• W2019392590 citedByCount "12" @default.
• W2019392590 countsByYear W20193925902012 @default.
• W2019392590 countsByYear W20193925902013 @default.
• W2019392590 countsByYear W20193925902014 @default.
• W2019392590 countsByYear W20193925902016 @default.
• W2019392590 countsByYear W20193925902022 @default.
• W2019392590 crossrefType "journal-article" @default.
• W2019392590 hasAuthorship W2019392590A5012837780 @default.
• W2019392590 hasAuthorship W2019392590A5050346471 @default.
• W2019392590 hasAuthorship W2019392590A5056220797 @default.
• W2019392590 hasAuthorship W2019392590A5087490208 @default.
• W2019392590 hasConcept C104317684 @default.
• W2019392590 hasConcept C126322002 @default.
• W2019392590 hasConcept C127561419 @default.
• W2019392590 hasConcept C140149449 @default.
• W2019392590 hasConcept C1491633281 @default.
• W2019392590 hasConcept C153911025 @default.
• W2019392590 hasConcept C177336024 @default.
• W2019392590 hasConcept C186198217 @default.
• W2019392590 hasConcept C190283241 @default.
• W2019392590 hasConcept C203522944 @default.
• W2019392590 hasConcept C2776415932 @default.
• W2019392590 hasConcept C522857546 @default.
• W2019392590 hasConcept C55493867 @default.
• W2019392590 hasConcept C62478195 @default.
• W2019392590 hasConcept C71924100 @default.
• W2019392590 hasConcept C75217442 @default.
• W2019392590 hasConcept C86554907 @default.
• W2019392590 hasConcept C86803240 @default.
• W2019392590 hasConcept C95444343 @default.
• W2019392590 hasConceptScore W2019392590C104317684 @default.
• W2019392590 hasConceptScore W2019392590C126322002 @default.
• W2019392590 hasConceptScore W2019392590C127561419 @default.
• W2019392590 hasConceptScore W2019392590C140149449 @default.
• W2019392590 hasConceptScore W2019392590C1491633281 @default.
• W2019392590 hasConceptScore W2019392590C153911025 @default.
• W2019392590 hasConceptScore W2019392590C177336024 @default.
• W2019392590 hasConceptScore W2019392590C186198217 @default.
• W2019392590 hasConceptScore W2019392590C190283241 @default.
• W2019392590 hasConceptScore W2019392590C203522944 @default.
• W2019392590 hasConceptScore W2019392590C2776415932 @default.
• W2019392590 hasConceptScore W2019392590C522857546 @default.
• W2019392590 hasConceptScore W2019392590C55493867 @default.
• W2019392590 hasConceptScore W2019392590C62478195 @default.
• W2019392590 hasConceptScore W2019392590C71924100 @default.
• W2019392590 hasConceptScore W2019392590C75217442 @default.
• W2019392590 hasConceptScore W2019392590C86554907 @default.
• W2019392590 hasConceptScore W2019392590C86803240 @default.
• W2019392590 hasConceptScore W2019392590C95444343 @default.
• W2019392590 hasIssue "1" @default.
• W2019392590 hasLocation W20193925901 @default.
• W2019392590 hasOpenAccess W2019392590 @default.
• W2019392590 hasPrimaryLocation W20193925901 @default.
• W2019392590 hasRelatedWork W1972429475 @default.
• W2019392590 hasRelatedWork W2102785604 @default.
• W2019392590 hasRelatedWork W2261640996 @default.
• W2019392590 hasRelatedWork W2375775039 @default.
• W2019392590 hasRelatedWork W2794310004 @default.
• W2019392590 hasRelatedWork W2918803269 @default.
• W2019392590 hasRelatedWork W2984819485 @default.
• W2019392590 hasRelatedWork W3017695750 @default.
• W2019392590 hasRelatedWork W4379260097 @default.
• W2019392590 hasRelatedWork W945377105 @default.
• W2019392590 hasVolume "62" @default.
• W2019392590 isParatext "false" @default.

• next