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• W2019393670 abstract "Mutations in Toll-like receptor (TLR) and myeloid differentiation primary response 88 (MYD88) genes have been found in chronic lymphocytic leukemia (CLL) at low frequency. We analyzed the incidence, clinicobiological characteristics, and outcome of patients with TLR/MYD88mutations in 587 CLL patients. Twenty-three patients (3.9%) had mutations, 19 in MYD88(one with concurrent IRAK1mutation), 2 TLR2(one with concomitant TLR6mutation), 1 IRAK1, and 1 TLR5. No mutations were found in IRAK2and IRAK4. TLR/MYD88-mutated CLL overexpressed genes of the nuclear factor κB pathway. Patients with TLR/MYD88mutations were significantly younger (83% age ≤50 years) than those with no mutations. TLR/MYD88mutations were the most frequent in young patients. Patients with mutated TLR/MYD88CLL had a higher frequency of mutated IGHVand low expression of CD38 and ZAP-70. Overall survival (OS) was better in TLR/MYD88-mutated than unmutated patients in the whole series (10-year OS, 100% vs 62%; P= .002), and in the subset of patients age ≤50 years (100% vs 70%; P= .02). In addition, relative OS of TLR/MYD88-mutated patients was similar to that in the age- and gender-matched population. In summary, TLR/MYD88mutations identify a population of young CLL patients with favorable outcome." @default.
• W2019393670 created "2016-06-24" @default.
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• W2019393670 date "1980-07-01" @default.
• W2019393670 modified "2023-10-18" @default.
• W2019393670 title "The classification and pathology of the lymphomas and leukemias" @default.
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• W2019393670 doi "https://doi.org/10.1016/0037-198x(80)90047-4" @default.
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