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• W2019400003 abstract "The effects of intrathecal injections of F8Famide (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2, 0.05–17.5 nmol) and FMR-Famide (Phe-Met-Arg-Phe-NH2, 0.002–25 nmol), known as anti-opioid agents, were investigated by using noxious thermal (tail flick) and mechanical (paw pressure) tests in the rat. Both peptides produced significant long-lasting (24–48 h) analgesia in both tests without causing detectable motor dysfunction. Pretreatment with systematic naloxone (5.5 μmol/kg i.p.) attenuated the initial antinociceptive effects (first hour) induced by both peptides (8.8 nmol) in the tail flick test and only by FMRFamide in the paw pressure test. A subeffective dose of F8Famide (0.05 nmol) enhanced both the intensity and the duration of spinal morphine (6.6 nmol) analgesia in both tests. In contrast, a subanalgesic dose of FMRFamide (0.002 nmol) decreased the intensity and enhanced the duration of the effect of morphine. These results show that, besides acting as antinociceptive agents in the spinal cord, F8Famide and FMRFamide could differentially modulate spinal opioid functions." @default.
• W2019400003 created "2016-06-24" @default.
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• W2019400003 date "1993-06-01" @default.
• W2019400003 modified "2023-09-25" @default.
• W2019400003 title "Antinociceptive effects of intrathecally administered F8Famide and FMRFamide in the rat" @default.
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• W2019400003 doi "https://doi.org/10.1016/0014-2999(93)90095-y" @default.
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