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- W2019403712 abstract "Gingival epithelial cells are the primary barrier to infection by periodontal pathogens. The production of chemotactic cytokines, including interleukin-8 (IL-8), is one mechanism the host uses in response to infection. In this study it was found that both gingival and oral epithelial cells produced IL-8, but after infection with the periodontal pathogenPorphyromonas gingivalis, accumulation of the cytokine could not be detected. Northern analysis established that infected epithelial cells still expressed IL-8 mRNA, suggesting that the cytokine was destroyed after secretion. Incubation of IL-8 withP. gingivaliscells resulted in rapid loss of the cytokine; however, in the presence of a protease inhibitor the loss was significantly retarded, indicating that IL-8 was degraded byP. gingivalisproteases." @default.
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- W2019403712 modified "2023-10-02" @default.
- W2019403712 title "IL-8 degradation byPorphyromonas gingivalisproteases" @default.
- W2019403712 doi "https://doi.org/10.1006/mpat.1998.0277" @default.
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