FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019407986> ?p ?o ?g. }

• W2019407986 endingPage "2350" @default.
• W2019407986 startingPage "2342" @default.
• W2019407986 abstract "In patients with non-insulin-dependent diabetes mellitus (NIDDM) and matched control subjects we examined the interrelationships between in vivo nonoxidative glucose metabolism and glucose oxidation and the muscle activities, as well as the immunoreactive protein and mRNA levels of the rate-limiting enzymes in glycogen synthesis and glycolysis, glycogen synthase (GS) and phosphofructokinase (PFK), respectively. Analysis of biopsies of quadriceps muscle from 19 NIDDM patients and 19 control subjects showed in the basal state a 30% decrease (P < 0.005) in total GS activity and a 38% decrease (P < 0.001) in GS mRNA/microgram DNA in NIDDM patients, whereas the GS protein level was normal. The enzymatic activity and protein and mRNA levels of PFK were all normal in diabetic patients. In subgroups of NIDDM patients and control subjects an insulin-glucose clamp in combination with indirect calorimetry was performed. The rate of insulin-stimulated nonoxidative glucose metabolism was decreased by 47% (P < 0.005) in NIDDM patients, whereas the glucose oxidation rate was normal. The PFK activity, protein level, and mRNA/microgram DNA remained unchanged. The relative activation of GS by glucose-6-phosphate was 33% lower (P < 0.02), whereas GS mRNA/micrograms DNA was 37% lower (P < 0.05) in the diabetic patients after 4 h of hyperinsulinemia. Total GS immunoreactive mass remained normal. In conclusion, qualitative but not quantitative posttranslational abnormalities of the GS protein in muscle determine the reduced insulin-stimulated nonoxidative glucose metabolism in NIDDM." @default.
• W2019407986 created "2016-06-24" @default.
• W2019407986 creator A5007631249 @default.
• W2019407986 creator A5020304503 @default.
• W2019407986 creator A5026488520 @default.
• W2019407986 creator A5055775715 @default.
• W2019407986 creator A5061864636 @default.
• W2019407986 date "1993-06-01" @default.
• W2019407986 modified "2023-10-15" @default.
• W2019407986 title "Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus." @default.
• W2019407986 cites W114840752 @default.
• W2019407986 cites W1484942335 @default.
• W2019407986 cites W1562140236 @default.
• W2019407986 cites W1573035118 @default.
• W2019407986 cites W1589222013 @default.
• W2019407986 cites W1775749144 @default.
• W2019407986 cites W1789692956 @default.
• W2019407986 cites W1824154145 @default.
• W2019407986 cites W1830863052 @default.
• W2019407986 cites W18386041 @default.
• W2019407986 cites W1942971202 @default.
• W2019407986 cites W1966755400 @default.
• W2019407986 cites W1966755938 @default.
• W2019407986 cites W1972663144 @default.
• W2019407986 cites W1977182622 @default.
• W2019407986 cites W1977779461 @default.
• W2019407986 cites W1980660237 @default.
• W2019407986 cites W1982688466 @default.
• W2019407986 cites W1986933516 @default.
• W2019407986 cites W1994667169 @default.
• W2019407986 cites W1997050449 @default.
• W2019407986 cites W2018683948 @default.
• W2019407986 cites W2021900417 @default.
• W2019407986 cites W2031965656 @default.
• W2019407986 cites W2032622596 @default.
• W2019407986 cites W2034766774 @default.
• W2019407986 cites W2041814414 @default.
• W2019407986 cites W2042254778 @default.
• W2019407986 cites W2042524830 @default.
• W2019407986 cites W2051742997 @default.
• W2019407986 cites W2055245942 @default.
• W2019407986 cites W2062404580 @default.
• W2019407986 cites W2075855413 @default.
• W2019407986 cites W2084374961 @default.
• W2019407986 cites W2093415114 @default.
• W2019407986 cites W2094083698 @default.
• W2019407986 cites W2105717889 @default.
• W2019407986 cites W2105912552 @default.
• W2019407986 cites W2106563675 @default.
• W2019407986 cites W2110579274 @default.
• W2019407986 cites W2111628818 @default.
• W2019407986 cites W2116024321 @default.
• W2019407986 cites W2124232607 @default.
• W2019407986 cites W2131501155 @default.
• W2019407986 cites W2132136543 @default.
• W2019407986 cites W2134812217 @default.
• W2019407986 cites W2146877877 @default.
• W2019407986 cites W2149397303 @default.
• W2019407986 cites W2155875957 @default.
• W2019407986 cites W2171543951 @default.
• W2019407986 cites W2289466277 @default.
• W2019407986 cites W2330505590 @default.
• W2019407986 cites W2339028964 @default.
• W2019407986 cites W2341717561 @default.
• W2019407986 cites W263672935 @default.
• W2019407986 cites W2801973984 @default.
• W2019407986 cites W4210965190 @default.
• W2019407986 doi "https://doi.org/10.1172/jci116466" @default.
• W2019407986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/443291" @default.
• W2019407986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8514849" @default.
• W2019407986 hasPublicationYear "1993" @default.
• W2019407986 type Work @default.
• W2019407986 sameAs 2019407986 @default.
• W2019407986 citedByCount "94" @default.
• W2019407986 countsByYear W20194079862012 @default.
• W2019407986 countsByYear W20194079862013 @default.
• W2019407986 countsByYear W20194079862014 @default.
• W2019407986 countsByYear W20194079862015 @default.
• W2019407986 countsByYear W20194079862016 @default.
• W2019407986 countsByYear W20194079862017 @default.
• W2019407986 countsByYear W20194079862018 @default.
• W2019407986 countsByYear W20194079862019 @default.
• W2019407986 countsByYear W20194079862021 @default.
• W2019407986 countsByYear W20194079862022 @default.
• W2019407986 crossrefType "journal-article" @default.
• W2019407986 hasAuthorship W2019407986A5007631249 @default.
• W2019407986 hasAuthorship W2019407986A5020304503 @default.
• W2019407986 hasAuthorship W2019407986A5026488520 @default.
• W2019407986 hasAuthorship W2019407986A5055775715 @default.
• W2019407986 hasAuthorship W2019407986A5061864636 @default.
• W2019407986 hasBestOaLocation W20194079861 @default.
• W2019407986 hasConcept C122245378 @default.
• W2019407986 hasConcept C126322002 @default.
• W2019407986 hasConcept C134018914 @default.
• W2019407986 hasConcept C17093226 @default.
• W2019407986 hasConcept C192118531 @default.
• W2019407986 hasConcept C20251656 @default.
• W2019407986 hasConcept C2777499176 @default.

• next