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- W2019408026 abstract "The biochemical activity of lysozyme and the immunohistochemical cellular localization of lysozyme were studied in germ-free and conventionally reared rats. In comparison to conventionally reared rats, germ-free rats had significantly lower concentrations of lysozyme in the salivary gland, duodenum, colon, spleen, bone marrow and serum. Lysozyme concentrations were also lower, though not significantly so in the lung and the liver. By contrast, increased levels of lysozyme were observed in the thymus and ileum of germfree in comparison with conventionally reared rats. No lysozyme was detected in the urine or in the intestinal content of the ileum or the colon of either group. Lysozyme was detected by immunoperoxidase staining in the proximal tubules of the kidney, in the alveolar macrophages and in the Paneth cells of the small intestine in both germ-free and conventionally reared rats. However, in the Paneth cells of the ileum an increased intracellular concentration of lysozyme was observed in the germ-free rats. Moreover in the thymus of germ-free rats, lysozyme-positive reticular cells were observed that could not be localized in the thymus of conventionally reared rats. In addition to the observed low levels of immunoglobulins and complement, a relative lack of lysozyme could play a part in the increased susceptibility to infection of germ-free rats." @default.
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- W2019408026 date "2009-08-15" @default.
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- W2019408026 title "CONCENTRATION AND IMMUNOHISTOCHEMICAL LOCALIZATION OF LYSOZYME IN GERM-FREE AND CONVENTIONALLY REARED RATS" @default.
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- W2019408026 doi "https://doi.org/10.1111/j.1699-0463.1974.tb00393.x" @default.
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