FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019408053> ?p ?o ?g. }

• W2019408053 endingPage "100" @default.
• W2019408053 startingPage "91" @default.
• W2019408053 abstract "Reactive oxygen species, including superoxide, are important mediators of the pathophysiology of hypertension. In the vasculature, superoxide antagonizes nitric oxide (NO•), resulting in increased vascular tone. The GTP binding protein Rac regulates a wide variety of cellular functions, including the activation of NADPH oxidase, the major source of O2•− in the blood vessel wall. An hypothesis is that Rac1 may act as an important regulator of vascular O2•− production, contributing to the balance between O2•− and NO• and maintaining consequent homeostasis of blood pressure. To alter the activity of vascular NADPH oxidase, the authors developed a transgenic animal model that overexpresses the human cDNA of the constitutively active mutant of Rac1 (RacCA) in smooth muscle cells using the smooth muscle ±-actin promoter. The RacCA transgenic had excessive amounts of O2•− in the vessel wall that, which led to heightened production of peroxynitrite, as detected by increased protein nitration and reduced NO• levels. RacCA mice developed moderate hypertension, which was corrected by N-acetyl-L-cysteine (NAC). RacCA transgenic mice also developed left ventricular hypertrophy as a secondary effect of pressure overload. The data suggest that Rac1 is a critical regulator of the redox state of blood vessels and homeostasis of blood pressure." @default.
• W2019408053 created "2016-06-24" @default.
• W2019408053 creator A5006169846 @default.
• W2019408053 creator A5014174074 @default.
• W2019408053 creator A5016093423 @default.
• W2019408053 creator A5017918855 @default.
• W2019408053 creator A5021741496 @default.
• W2019408053 creator A5036906923 @default.
• W2019408053 creator A5053625408 @default.
• W2019408053 creator A5060576956 @default.
• W2019408053 creator A5069504896 @default.
• W2019408053 creator A5073705146 @default.
• W2019408053 creator A5073925608 @default.
• W2019408053 creator A5075294219 @default.
• W2019408053 creator A5091592009 @default.
• W2019408053 date "2007-01-01" @default.
• W2019408053 modified "2023-10-03" @default.
• W2019408053 title "Hypertension Caused by Transgenic Overexpression of Rac1" @default.
• W2019408053 cites W1486040868 @default.
• W2019408053 cites W1821918060 @default.
• W2019408053 cites W1974739160 @default.
• W2019408053 cites W1976555160 @default.
• W2019408053 cites W1981777416 @default.
• W2019408053 cites W1998020776 @default.
• W2019408053 cites W1998043006 @default.
• W2019408053 cites W1999868274 @default.
• W2019408053 cites W2027498284 @default.
• W2019408053 cites W2045067074 @default.
• W2019408053 cites W2050420714 @default.
• W2019408053 cites W2054255553 @default.
• W2019408053 cites W2068196116 @default.
• W2019408053 cites W2078349330 @default.
• W2019408053 cites W2085247268 @default.
• W2019408053 cites W2091193879 @default.
• W2019408053 cites W2093217834 @default.
• W2019408053 cites W2096583106 @default.
• W2019408053 cites W2103243895 @default.
• W2019408053 cites W2105767342 @default.
• W2019408053 cites W2110182057 @default.
• W2019408053 cites W2117535099 @default.
• W2019408053 cites W2123799914 @default.
• W2019408053 cites W2165212425 @default.
• W2019408053 cites W2169466315 @default.
• W2019408053 cites W2253572376 @default.
• W2019408053 doi "https://doi.org/10.1089/ars.2007.9.91" @default.
• W2019408053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17115888" @default.
• W2019408053 hasPublicationYear "2007" @default.
• W2019408053 type Work @default.
• W2019408053 sameAs 2019408053 @default.
• W2019408053 citedByCount "37" @default.
• W2019408053 countsByYear W20194080532012 @default.
• W2019408053 countsByYear W20194080532013 @default.
• W2019408053 countsByYear W20194080532014 @default.
• W2019408053 countsByYear W20194080532016 @default.
• W2019408053 countsByYear W20194080532017 @default.
• W2019408053 countsByYear W20194080532021 @default.
• W2019408053 countsByYear W20194080532022 @default.
• W2019408053 countsByYear W20194080532023 @default.
• W2019408053 crossrefType "journal-article" @default.
• W2019408053 hasAuthorship W2019408053A5006169846 @default.
• W2019408053 hasAuthorship W2019408053A5014174074 @default.
• W2019408053 hasAuthorship W2019408053A5016093423 @default.
• W2019408053 hasAuthorship W2019408053A5017918855 @default.
• W2019408053 hasAuthorship W2019408053A5021741496 @default.
• W2019408053 hasAuthorship W2019408053A5036906923 @default.
• W2019408053 hasAuthorship W2019408053A5053625408 @default.
• W2019408053 hasAuthorship W2019408053A5060576956 @default.
• W2019408053 hasAuthorship W2019408053A5069504896 @default.
• W2019408053 hasAuthorship W2019408053A5073705146 @default.
• W2019408053 hasAuthorship W2019408053A5073925608 @default.
• W2019408053 hasAuthorship W2019408053A5075294219 @default.
• W2019408053 hasAuthorship W2019408053A5091592009 @default.
• W2019408053 hasConcept C102230213 @default.
• W2019408053 hasConcept C104317684 @default.
• W2019408053 hasConcept C126322002 @default.
• W2019408053 hasConcept C134018914 @default.
• W2019408053 hasConcept C141035611 @default.
• W2019408053 hasConcept C181199279 @default.
• W2019408053 hasConcept C185592680 @default.
• W2019408053 hasConcept C2778784160 @default.
• W2019408053 hasConcept C2779395532 @default.
• W2019408053 hasConcept C2779719074 @default.
• W2019408053 hasConcept C2780795997 @default.
• W2019408053 hasConcept C2992686903 @default.
• W2019408053 hasConcept C48349386 @default.
• W2019408053 hasConcept C519581460 @default.
• W2019408053 hasConcept C55493867 @default.
• W2019408053 hasConcept C63645605 @default.
• W2019408053 hasConcept C71924100 @default.
• W2019408053 hasConcept C86803240 @default.
• W2019408053 hasConcept C95444343 @default.
• W2019408053 hasConceptScore W2019408053C102230213 @default.
• W2019408053 hasConceptScore W2019408053C104317684 @default.
• W2019408053 hasConceptScore W2019408053C126322002 @default.
• W2019408053 hasConceptScore W2019408053C134018914 @default.
• W2019408053 hasConceptScore W2019408053C141035611 @default.
• W2019408053 hasConceptScore W2019408053C181199279 @default.
• W2019408053 hasConceptScore W2019408053C185592680 @default.

• next