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- W2019409097 abstract "In vitro studies on cell lines may allow analyses of the mechanisms of immunogenicity and tolerogenicity in cells. We used a model of oncogenic transformation of an established murine macrophage cell line and report here that one v-mos-transformed clone expressing unaltered high amounts of MHC class I and II antigens does not induce proliferation of unprimed T cells in primary mixed lymphocyte reactions, in sharp contrast to its non-transformed parental cells. Interestingly, this clone induces specific unrespon-siveness, as revealed by the lack of responsiveness of MHC-specific T cells when subsequently exposed to the pertinent MHC alloantigens in immunogenic form but unaltered MHC-third party responsiveness of the naive spleen T cells. Furthermore, the accessory function of this clone is strongly reduced. These functional defects could be overcome by the addition of exogenous interleukin-1α (IL-1α). Analysis of mRNA expression showed a significant and selective reduction of IL-1α mRNA levels when compared with parental cells." @default.
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- W2019409097 date "1993-07-01" @default.
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- W2019409097 title "Oncogene Transformation can induce Tolerogenicity in Murine Macrophages after Down-Regulation of Immunogenicity without altering Major Histocompatibility Complex Antigen Expression" @default.
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- W2019409097 doi "https://doi.org/10.1111/j.1365-3083.1993.tb01693.x" @default.
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