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• W2019410556 abstract "The chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3′,5′-monophosphate (cAMP) was studied using microfluidic devices. In shallow gradients of less than 10−3 nM/μm, the cells showed no directional response and exhibited a constant basal motility. In steeper gradients, cells moved up the gradient on average. The chemotactic speed and the motility increased with increasing steepness up to a plateau at around 10−1 nM/μm. In very steep gradients, above 10 nM/μm, the cells lost directionality and the motility returned to the sub-threshold level. In the regime of optimal response the difference in receptor occupancy at the front and back of the cell is estimated to be only about 100 molecules." @default.
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• W2019410556 date "2006-09-01" @default.
• W2019410556 modified "2023-10-12" @default.
• W2019410556 title "Dictyostelium discoideum chemotaxis: Threshold for directed motion" @default.
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• W2019410556 doi "https://doi.org/10.1016/j.ejcb.2006.01.012" @default.
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