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• W2019412823 abstract "There are few studies of sustained-release bupropion in adolescents with major depression.Twenty-one adolescents with DSM-IV major depression were recruited through advertisement and self-referral; 11 began study medication and were rated weekly with an expanded Hamilton Depression Rating Scale (SIGH-SAD), as well as Clinical Global Impression-Improvement (CGI-I).Of 11 subjects enrolled, 8 completed an 8-week trial of bupropion SR. Mean baseline SIGH-SAD scores of 31.3 decreased significantly by 74% to mean endpoint score of 8.2. Improvement on CGI-I that agreed closely between raters and patients was found in 8 of 11 subjects (72.3%). The mean daily dose of bupropion SR was 362 mg +/- 52 mg and was well tolerated; insomnia and weight loss were experienced by 55%; other adverse effects of dry mouth, headache, agitation, light-headedness, diarrhea, or rash were noted in a minority of subjects.In this preliminary, small open study, depressed adolescents showed a marked response to bupropion SR." @default.
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• W2019412823 date "2003-07-01" @default.
• W2019412823 modified "2023-09-24" @default.
• W2019412823 title "Open Trial of Bupropion SR in Adolescent Major Depression" @default.
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• W2019412823 doi "https://doi.org/10.1111/j.1744-6171.2003.00123.x" @default.
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