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• W2019412963 abstract "In this study, we investigated the ligand-mediated regulation of retinoid X receptor (RXR) in two human cell lines (HepG2 and JEG-3 cells), which have been reported to express RXRα predominantly. Western blot analysis revealed that a treatment with 1 μM 9-cis-retinoic acid (9-cis RA) for 24 h decreased RXRα protein level to 72 ± 9 and 75 ± 7% in HepG2 and JEG-3 cells, respectively, when the levels in the non-treated cells were expressed as 100%. The decrease was not due to the changes in steady-state level of RXRα mRNA or its stability as revealed by Northern blot analysis. However, the 9-cis RA treatment decreased the half-life of RXRα protein as determined by pulse-chase analysis. It was thus demonstrated that 9-cis RA downregulates RXRα by increasing the turnover of the protein in the two cell lines. The ligand-dependent downregulation of RXRα protein may be important for several hormonal signalings, in which the receptors heterodimerize with RXR." @default.
• W2019412963 created "2016-06-24" @default.
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• W2019412963 date "1999-07-01" @default.
• W2019412963 modified "2023-09-28" @default.
• W2019412963 title "9-cis-Retinoic Acid Decreases the Level of Its Cognate Receptor, Retinoid X Receptor, through Acceleration of the Turnover" @default.
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• W2019412963 doi "https://doi.org/10.1006/bbrc.1999.0969" @default.
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