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• W2019413638 abstract "SDF-1/CXCR4 plays an important role in promoting survival, expansion, and differentiation of T cell progenitors. The present study investigates the mechanism by which estrogen inhibits SDF-1alpha expression in mouse thymus. Mouse estrogen enhanced transcript (mEET) is endogenously expressed in a mouse thymus epithelial cell line 1 (MTEC1). In MTEC1 cells that express the transfected sense mEET, the SDF-1alpha transcription and its chemotactic activity were profoundly inhibited. Conversely, in MTEC1 that express the transfected anti-sense mEET, the SDF-1alpha transcription and its chemotactic activity were substantially augmented. Moreover, we disclosed that mEET inhibited the production of SDF-1alpha by its suppression of NF-kappaB translocation into nucleus. Using a combinatorial induction of doxycycline (Dox) and 17beta-estradiol (E2) on the sense and anti-sense mEET transfectants, it was demonstrated that an increase of mEET expression enhanced E2-induced inhibition of SDF-1alpha production, while a blockade of mEET expression alleviated E2-induced inhibition of SDF-1alpha production. In conclusion, the E2-imposed suppression of SDF-1alpha production is partly mediated by mEET involved signaling pathway." @default.
• W2019413638 created "2016-06-24" @default.
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• W2019413638 date "2003-05-01" @default.
• W2019413638 modified "2023-10-18" @default.
• W2019413638 title "SDF-1α production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line" @default.
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• W2019413638 doi "https://doi.org/10.1016/s0008-8749(03)00152-7" @default.
• W2019413638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12914755" @default.
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