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- W2019415427 abstract "NGF is important for the differentiation and maintenance of the sympathetic nervous system and EGF promotes eyelid opening, tooth eruption and maturation of the intestine in newborn mice. Both growth factors are present in high concentrations in mouse submandibular gland (SMG) and distributed in lesser amounts in many mouse and human body fluids and tissues. The present study was conducted to prove the biological activity of milk-NGF and to characterize the ontogeny of NGF and EGF and molecular profile of EGF in early lactation in normal and sialoadenoectomized mice to determine whether the SMG contributes significantly to milk growth factors. Concentrations of NGF, determined by RIA, did not change from day 1 to day 9 of lactation (600 pg/mg protein) and were not different in sialoadenoectomized mice. Biological activity was proven by PC-12 bioassay after partial purification. EGF showed only one component, similar to SMG-EGF (MW 6045), in gel exclusion chromatography, but removal of the SMG did not change the concentration which peaked around day 6 of lactation (10 ng/mg protein). Conclusion: Growth factors are present in significant concentrations in mouse milk and the SMG is not their origin." @default.
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- W2019415427 date "1984-11-01" @default.
- W2019415427 modified "2023-09-23" @default.
- W2019415427 title "Nerve growth factor (NGF) and epidermal growth factor (EGF) are present in mouse milk during early lactation" @default.
- W2019415427 doi "https://doi.org/10.1203/00006450-198411000-00067" @default.
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