FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019416105> ?p ?o ?g. }

• W2019416105 abstract "You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 2011762 ENOS LOCALIZES TO MYOENDOTHELIAL JUNCTIONS IN THE CORPUS CAVERNOSUM: IMPLICATIONS FOR ERECTILE DYSFUNCTION Gregory Lowe, Adam Straub, Joan Ko, Robin Woodson, Parviz Kavoussi, Raymond Costabile, William Steers, Brant Isakson, and Jeffrey Lysiak Gregory LoweGregory Lowe Charlottesville, VA More articles by this author , Adam StraubAdam Straub Charlottesville, VA More articles by this author , Joan KoJoan Ko Charlottesville, VA More articles by this author , Robin WoodsonRobin Woodson Charlottesville, VA More articles by this author , Parviz KavoussiParviz Kavoussi Austin, TX More articles by this author , Raymond CostabileRaymond Costabile Charlottesville, VA More articles by this author , William SteersWilliam Steers Charlottesville, VA More articles by this author , Brant IsaksonBrant Isakson Charlottesville, VA More articles by this author , and Jeffrey LysiakJeffrey Lysiak Charlottesville, VA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1787AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Myoendothelial junctions (MEJs) are cellular extensions through the internal elastic lamina between endothelial cells (EC) and vascular smooth muscle cells (VSMC) that link the membranes of the two cell types. MEJs provide apposition of the EC and VSMC allowing efficient heterocellular communication and gap junction formation. Our group recently reported that a transgenic mouse strain that lacks MEJs has erectile dysfunction (ED) and that after cavernous nerve resection MEJs are lost in the corporal tissue. Endothelial nitric oxide synthase (eNOS) is critical for the generation of nitric oxide (NO) and the erectile response. We now report that eNOS is localized to the MEJs suggesting a targeted release of NO to the VSMC. METHODS Wild-type male C57BL/6 mice between 8–12 weeks of age were studied according to the University of Virginia Animal Care and Use Committee guidelines. Each animal was perfused and penile cavernosal tissue was harvested. Tissues were fixed in 4% paraformaldehyde/0.5% glutaraldehyde and embedded in lowcril white, prior to being sectioned and immunolabeled for eNOS. Images were then obtained on a Joel 1220 transmission electron microscope. RESULTS Electron microscopic imaging of the cavernosal tissue revealed the presence of MEJs. The majority of specific eNOS labeling was localized to the MEJs in the corpus cavernosum. eNOS was only observed occasionally elsewhere in the endothelial cells. CONCLUSIONS eNOS localization to MEJs within the corpus cavernosum provides an efficient means of EC-VSMC communication necessary for the targeted release of NO by the EC. This data also demonstrates that eNOS is not randomly distributed in the EC in the corporal tissue and localization to the MEJs may be necessary for maximal eNOS activation and subsequent NO production and targeted delivery to the VSMC. We are currently exploring if factors influencing eNOS activation also are present in MEJs. Both eNOS and MEJs are critical for the erectile response thus an understanding of their relationship will provide basic knowledge of the mammalian erectile response. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e306 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Metrics Author Information Gregory Lowe Charlottesville, VA More articles by this author Adam Straub Charlottesville, VA More articles by this author Joan Ko Charlottesville, VA More articles by this author Robin Woodson Charlottesville, VA More articles by this author Parviz Kavoussi Austin, TX More articles by this author Raymond Costabile Charlottesville, VA More articles by this author William Steers Charlottesville, VA More articles by this author Brant Isakson Charlottesville, VA More articles by this author Jeffrey Lysiak Charlottesville, VA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2019416105 created "2016-06-24" @default.
• W2019416105 creator A5027364359 @default.
• W2019416105 creator A5036017969 @default.
• W2019416105 creator A5037296949 @default.
• W2019416105 creator A5038136326 @default.
• W2019416105 creator A5041652901 @default.
• W2019416105 creator A5044351066 @default.
• W2019416105 creator A5060365830 @default.
• W2019416105 creator A5079581156 @default.
• W2019416105 creator A5086817262 @default.
• W2019416105 date "2011-04-01" @default.
• W2019416105 modified "2023-10-06" @default.
• W2019416105 title "762 ENOS LOCALIZES TO MYOENDOTHELIAL JUNCTIONS IN THE CORPUS CAVERNOSUM: IMPLICATIONS FOR ERECTILE DYSFUNCTION" @default.
• W2019416105 doi "https://doi.org/10.1016/j.juro.2011.02.1787" @default.
• W2019416105 hasPublicationYear "2011" @default.
• W2019416105 type Work @default.
• W2019416105 sameAs 2019416105 @default.
• W2019416105 citedByCount "0" @default.
• W2019416105 crossrefType "journal-article" @default.
• W2019416105 hasAuthorship W2019416105A5027364359 @default.
• W2019416105 hasAuthorship W2019416105A5036017969 @default.
• W2019416105 hasAuthorship W2019416105A5037296949 @default.
• W2019416105 hasAuthorship W2019416105A5038136326 @default.
• W2019416105 hasAuthorship W2019416105A5041652901 @default.
• W2019416105 hasAuthorship W2019416105A5044351066 @default.
• W2019416105 hasAuthorship W2019416105A5060365830 @default.
• W2019416105 hasAuthorship W2019416105A5079581156 @default.
• W2019416105 hasAuthorship W2019416105A5086817262 @default.
• W2019416105 hasConcept C105702510 @default.
• W2019416105 hasConcept C126322002 @default.
• W2019416105 hasConcept C134018914 @default.
• W2019416105 hasConcept C2777622882 @default.
• W2019416105 hasConcept C2777786686 @default.
• W2019416105 hasConcept C2778326061 @default.
• W2019416105 hasConcept C2779929075 @default.
• W2019416105 hasConcept C2992676626 @default.
• W2019416105 hasConcept C519581460 @default.
• W2019416105 hasConcept C71924100 @default.
• W2019416105 hasConceptScore W2019416105C105702510 @default.
• W2019416105 hasConceptScore W2019416105C126322002 @default.
• W2019416105 hasConceptScore W2019416105C134018914 @default.
• W2019416105 hasConceptScore W2019416105C2777622882 @default.
• W2019416105 hasConceptScore W2019416105C2777786686 @default.
• W2019416105 hasConceptScore W2019416105C2778326061 @default.
• W2019416105 hasConceptScore W2019416105C2779929075 @default.
• W2019416105 hasConceptScore W2019416105C2992676626 @default.
• W2019416105 hasConceptScore W2019416105C519581460 @default.
• W2019416105 hasConceptScore W2019416105C71924100 @default.
• W2019416105 hasIssue "4S" @default.
• W2019416105 hasLocation W20194161051 @default.
• W2019416105 hasOpenAccess W2019416105 @default.
• W2019416105 hasPrimaryLocation W20194161051 @default.
• W2019416105 hasRelatedWork W114349860 @default.
• W2019416105 hasRelatedWork W1984685645 @default.
• W2019416105 hasRelatedWork W2348960866 @default.
• W2019416105 hasRelatedWork W2391843134 @default.
• W2019416105 hasRelatedWork W2971811956 @default.
• W2019416105 hasRelatedWork W3141225058 @default.
• W2019416105 hasRelatedWork W3150803062 @default.
• W2019416105 hasRelatedWork W3174123384 @default.
• W2019416105 hasRelatedWork W4253078486 @default.
• W2019416105 hasRelatedWork W57682727 @default.
• W2019416105 hasVolume "185" @default.
• W2019416105 isParatext "false" @default.
• W2019416105 isRetracted "false" @default.
• W2019416105 magId "2019416105" @default.
• W2019416105 workType "article" @default.