Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019419150> ?p ?o ?g. }
- W2019419150 endingPage "1468" @default.
- W2019419150 startingPage "1461" @default.
- W2019419150 abstract "Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or basement‑membrane‑40 (BM‑40), is a matrix‑associated protein that elicits changes in cell shape, inhibits cell‑cycle progression and affects the synthesis of extracellular matrix (ECM). The final mature SPARC protein has 286 amino acids with three distinct domains, including an NH2‑terminal acidic domain (NT), follistatin‑like domain (FS) and C terminus domain (EC). The present study identified SPARC genes from 14 vertebrate genomes and revealed that SPARC existed in all types of vertebrates, including fish, amphibians, birds and mammals. In total, 21 single nucleotide polymorphisms (SNPs) causing missense mutations were identified, which may affect the formation of the truncated form of the SPARC protein. The human SPARC gene was found to be expressed in numerous tissues or organs, including in the bone marrow, whole blood, lymph node, thymus, brain, cerebellum, retina, heart, smooth muscle, skeletal muscle, spinal cord, intestine, colon, adipocyte, kidney, liver, pancreas, thyroid, salivary gland, skin, ovary, uterus, placenta, cervix and prostate. When searched in the PrognoScan database, the human SPARC gene was also found to be expressed in bladder, blood, breast, glioma, esophagus, colorectal, head and neck, ovarian, lung and skin cancer tissues. It was revealed that the association between the expression of SPARC and prognosis varied in different types of cancer, and even in the same cancer from different databases. It implied that the function of SPARC in these tumors may be multidimensional, functioning not just as a tumor suppressor or oncogene." @default.
- W2019419150 created "2016-06-24" @default.
- W2019419150 creator A5003246573 @default.
- W2019419150 creator A5028873497 @default.
- W2019419150 creator A5031574868 @default.
- W2019419150 creator A5037740266 @default.
- W2019419150 creator A5056168495 @default.
- W2019419150 creator A5074339191 @default.
- W2019419150 date "2014-06-17" @default.
- W2019419150 modified "2023-09-30" @default.
- W2019419150 title "Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction" @default.
- W2019419150 cites W1524812740 @default.
- W2019419150 cites W1607267312 @default.
- W2019419150 cites W1880966939 @default.
- W2019419150 cites W1963606104 @default.
- W2019419150 cites W1966062502 @default.
- W2019419150 cites W1966720693 @default.
- W2019419150 cites W1976173969 @default.
- W2019419150 cites W1991897855 @default.
- W2019419150 cites W1996585606 @default.
- W2019419150 cites W2002901962 @default.
- W2019419150 cites W2005216036 @default.
- W2019419150 cites W2012795446 @default.
- W2019419150 cites W2014328430 @default.
- W2019419150 cites W2018162829 @default.
- W2019419150 cites W2021369237 @default.
- W2019419150 cites W2022335352 @default.
- W2019419150 cites W2024152221 @default.
- W2019419150 cites W2024903803 @default.
- W2019419150 cites W2029869414 @default.
- W2019419150 cites W2030145963 @default.
- W2019419150 cites W2031224113 @default.
- W2019419150 cites W2033513825 @default.
- W2019419150 cites W2033855791 @default.
- W2019419150 cites W2035575075 @default.
- W2019419150 cites W2048000549 @default.
- W2019419150 cites W2053491138 @default.
- W2019419150 cites W2065669229 @default.
- W2019419150 cites W2068627412 @default.
- W2019419150 cites W2068819752 @default.
- W2019419150 cites W2070526394 @default.
- W2019419150 cites W2074773146 @default.
- W2019419150 cites W2076314246 @default.
- W2019419150 cites W2076356585 @default.
- W2019419150 cites W2076812384 @default.
- W2019419150 cites W2078641709 @default.
- W2019419150 cites W2079849392 @default.
- W2019419150 cites W2086898231 @default.
- W2019419150 cites W2088160256 @default.
- W2019419150 cites W2088233050 @default.
- W2019419150 cites W2088393064 @default.
- W2019419150 cites W2088394753 @default.
- W2019419150 cites W2093899337 @default.
- W2019419150 cites W2095519478 @default.
- W2019419150 cites W2097382368 @default.
- W2019419150 cites W2100471807 @default.
- W2019419150 cites W2105829583 @default.
- W2019419150 cites W2106814707 @default.
- W2019419150 cites W2107284818 @default.
- W2019419150 cites W2108543860 @default.
- W2019419150 cites W2110016169 @default.
- W2019419150 cites W2126310598 @default.
- W2019419150 cites W2131593373 @default.
- W2019419150 cites W2133131759 @default.
- W2019419150 cites W2141026022 @default.
- W2019419150 cites W2141948661 @default.
- W2019419150 cites W2142736547 @default.
- W2019419150 cites W2146303969 @default.
- W2019419150 cites W2146396346 @default.
- W2019419150 cites W2147925490 @default.
- W2019419150 cites W2151834630 @default.
- W2019419150 cites W2155354546 @default.
- W2019419150 cites W2156808678 @default.
- W2019419150 cites W2160360616 @default.
- W2019419150 cites W2160364329 @default.
- W2019419150 cites W2260417393 @default.
- W2019419150 cites W2560874380 @default.
- W2019419150 cites W4243352947 @default.
- W2019419150 doi "https://doi.org/10.3892/mmr.2014.2339" @default.
- W2019419150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24938427" @default.
- W2019419150 hasPublicationYear "2014" @default.
- W2019419150 type Work @default.
- W2019419150 sameAs 2019419150 @default.
- W2019419150 citedByCount "13" @default.
- W2019419150 countsByYear W20194191502014 @default.
- W2019419150 countsByYear W20194191502015 @default.
- W2019419150 countsByYear W20194191502016 @default.
- W2019419150 countsByYear W20194191502018 @default.
- W2019419150 countsByYear W20194191502020 @default.
- W2019419150 countsByYear W20194191502021 @default.
- W2019419150 countsByYear W20194191502022 @default.
- W2019419150 countsByYear W20194191502023 @default.
- W2019419150 crossrefType "journal-article" @default.
- W2019419150 hasAuthorship W2019419150A5003246573 @default.
- W2019419150 hasAuthorship W2019419150A5028873497 @default.
- W2019419150 hasAuthorship W2019419150A5031574868 @default.
- W2019419150 hasAuthorship W2019419150A5037740266 @default.
- W2019419150 hasAuthorship W2019419150A5056168495 @default.