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• W2019420747 endingPage "244" @default.
• W2019420747 startingPage "233" @default.
• W2019420747 abstract "C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are endogenous inhibitors of the Src-family protein tyrosine kinases (SFKs). Since constitutive activation of SFKs contributes to cancer formation and progression, to prevent excessive activation of SFKs, their activity in normal cells is kept at the basal level by CSK and CHK. CSK and CHK inactivate SFKs by specifically phosphorylating a consensus tyrosine (called Y(T)) near their C-termini. Upon phosphorylation, the phospho-Y(T) engages in intramolecular interactions that lock the SFK molecule in an inactive conformation. SFKs are anchored to the plasma membrane, while CSK and CHK are localized predominantly in the cytosol. To inhibit SFKs, CSK and CHK need to translocate to the plasma membrane. Recruitment of CSK and CHK to the plasma membrane is mediated by the binding of their SH2, SH3 and/or kinase domains to specific transmembrane proteins, G-proteins and adaptor proteins located near the plasma membrane. For CSK, membrane recruitment often accompanies activation. CSK and CHK employ two types of direct interactions with SFKs to achieve efficient Y(T) phosphorylation: (i) short-range interactions involving binding of the active sites of CSK and CHK to specific residues near Y(T), (ii) long-range non-catalytic interactions involving binding of SFKs to motifs located distally from the active sites of CSK and CHK. The interactions between CSK and SFKs are transient in nature. Unlike CSK, CHK binds tightly to SFKs to form stable protein complexes. The binding is non-catalytic as it is independent of Y(T). More importantly, the tight binding alone is sufficient to completely inhibit SFKs. This non-catalytic inhibitory binding represents a novel mechanism employed by CHK to inhibit SFKs. Given that SFKs are implicated in cancer development, compounds mimicking the non-catalytic inhibitory mechanism of CHK are potential anti-cancer therapeutics." @default.
• W2019420747 created "2016-06-24" @default.
• W2019420747 creator A5038232997 @default.
• W2019420747 creator A5057990375 @default.
• W2019420747 creator A5065335424 @default.
• W2019420747 date "2005-01-01" @default.
• W2019420747 modified "2023-09-26" @default.
• W2019420747 title "C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)—endogenous negative regulators of Src-family protein kinases" @default.
• W2019420747 cites W1548078808 @default.
• W2019420747 cites W1549736588 @default.
• W2019420747 cites W1553517909 @default.
• W2019420747 cites W1582379379 @default.
• W2019420747 cites W1594706458 @default.
• W2019420747 cites W1762601568 @default.
• W2019420747 cites W1881522644 @default.
• W2019420747 cites W1934287581 @default.
• W2019420747 cites W1967897783 @default.
• W2019420747 cites W1970973812 @default.
• W2019420747 cites W1974561108 @default.
• W2019420747 cites W1976508520 @default.
• W2019420747 cites W1976662277 @default.
• W2019420747 cites W1977455794 @default.
• W2019420747 cites W1979188601 @default.
• W2019420747 cites W1981660923 @default.
• W2019420747 cites W1981891742 @default.
• W2019420747 cites W1986366957 @default.
• W2019420747 cites W1986402178 @default.
• W2019420747 cites W1991683855 @default.
• W2019420747 cites W1992009506 @default.
• W2019420747 cites W1997546191 @default.
• W2019420747 cites W2003570140 @default.
• W2019420747 cites W2003904482 @default.
• W2019420747 cites W2004771750 @default.
• W2019420747 cites W2007058418 @default.
• W2019420747 cites W2010318629 @default.
• W2019420747 cites W2011588737 @default.
• W2019420747 cites W2017466223 @default.
• W2019420747 cites W2019182965 @default.
• W2019420747 cites W2020537787 @default.
• W2019420747 cites W2026279585 @default.
• W2019420747 cites W2026331945 @default.
• W2019420747 cites W2026522709 @default.
• W2019420747 cites W2030577752 @default.
• W2019420747 cites W2033444434 @default.
• W2019420747 cites W2034152669 @default.
• W2019420747 cites W2036107389 @default.
• W2019420747 cites W2037060847 @default.
• W2019420747 cites W2038718210 @default.
• W2019420747 cites W2042824379 @default.
• W2019420747 cites W2043761739 @default.
• W2019420747 cites W2049360086 @default.
• W2019420747 cites W2050973237 @default.
• W2019420747 cites W2054906811 @default.
• W2019420747 cites W2058609758 @default.
• W2019420747 cites W2062256468 @default.
• W2019420747 cites W2064529356 @default.
• W2019420747 cites W2065289702 @default.
• W2019420747 cites W2065587675 @default.
• W2019420747 cites W2067771516 @default.
• W2019420747 cites W2070696612 @default.
• W2019420747 cites W2073209391 @default.
• W2019420747 cites W2075265463 @default.
• W2019420747 cites W2079252551 @default.
• W2019420747 cites W2080568049 @default.
• W2019420747 cites W2088365475 @default.
• W2019420747 cites W2088809390 @default.
• W2019420747 cites W2089827156 @default.
• W2019420747 cites W2090831635 @default.
• W2019420747 cites W2095372350 @default.
• W2019420747 cites W2097596648 @default.
• W2019420747 cites W2101257013 @default.
• W2019420747 cites W2102098900 @default.
• W2019420747 cites W2102101621 @default.
• W2019420747 cites W2108914190 @default.
• W2019420747 cites W2111941226 @default.
• W2019420747 cites W2112418598 @default.
• W2019420747 cites W2114449882 @default.
• W2019420747 cites W2116931858 @default.
• W2019420747 cites W2118738797 @default.
• W2019420747 cites W2127715226 @default.
• W2019420747 cites W2138067522 @default.
• W2019420747 cites W2140592033 @default.
• W2019420747 cites W2143548354 @default.
• W2019420747 cites W2144515789 @default.
• W2019420747 cites W2148006813 @default.
• W2019420747 cites W2152498364 @default.
• W2019420747 cites W2159018836 @default.
• W2019420747 cites W2160675888 @default.
• W2019420747 cites W2161733130 @default.
• W2019420747 cites W2163905724 @default.
• W2019420747 cites W2166127280 @default.
• W2019420747 cites W2167305208 @default.
• W2019420747 cites W2168601978 @default.
• W2019420747 cites W2339422997 @default.
• W2019420747 cites W2345882597 @default.
• W2019420747 cites W29860350 @default.
• W2019420747 cites W317592431 @default.
• W2019420747 doi "https://doi.org/10.1080/08977190500178877" @default.

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