FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019424369> ?p ?o ?g. }

• W2019424369 endingPage "576" @default.
• W2019424369 startingPage "563" @default.
• W2019424369 abstract "Highly immunogenic (xenogenized) tumour variants appear after treatment of murine mastocytoma P815 with the triazene derivative DTIC, a phenomenon associated with the appearance of structurally abnormal p15E env proteins in the variant cells. In the present study, we have isolated and sequenced several p15E cDNA gene fragments amplified by means of polymerase chain reaction (PCR) from parental (P815) and xenogenized (P815/DTIC) tumour cells. Compared to known p15E sequences in parental cells, one p15E sequence from xenogenized cells presented three distinct nucleotide changes, one of which was apparently unique to P815/DTIC DNA and cDNA upon single-nucleotide primer extension assay. One major histocompatibility complex (MHC) class I-binding peptide, corresponding to a putative mutation in the p15E sequence, was tested in parallel with the parental peptide for recognition by P815/DTIC-specific cytotoxic T cells in vitro. The results suggested that the amino acid substitution at the relevant position of the p15E protein may produce an antigenic T cell epitope. By skin test assay of mice primed with either the synthetic peptide or P815/DTIC cells, evidence was obtained that the mutated peptide is immunogenic in vivo, and that the neoepitope is expressed by P815/DTIC cells. In accordance with previous data in the L5178Y/DTIC tumour model system, these findings reinforce the notion that xenogenization of tumour cells may result in the expression of class I-binding mutated peptides of retroviral origin." @default.
• W2019424369 created "2016-06-24" @default.
• W2019424369 creator A5003492189 @default.
• W2019424369 creator A5011703773 @default.
• W2019424369 creator A5045015927 @default.
• W2019424369 creator A5047813375 @default.
• W2019424369 creator A5079557352 @default.
• W2019424369 date "1996-10-01" @default.
• W2019424369 modified "2023-10-05" @default.
• W2019424369 title "A retroviral peptide encoded by mutated env p15E gene is recognized by specific CD8+ T lymphocytes on drug-treated murine mastocytoma P815" @default.
• W2019424369 cites W1507872614 @default.
• W2019424369 cites W1543625048 @default.
• W2019424369 cites W1556988513 @default.
• W2019424369 cites W1572805637 @default.
• W2019424369 cites W1871831132 @default.
• W2019424369 cites W1968299218 @default.
• W2019424369 cites W1991934910 @default.
• W2019424369 cites W2004920239 @default.
• W2019424369 cites W2008564146 @default.
• W2019424369 cites W2008577483 @default.
• W2019424369 cites W2011819374 @default.
• W2019424369 cites W2015419033 @default.
• W2019424369 cites W2028548278 @default.
• W2019424369 cites W2063903837 @default.
• W2019424369 cites W2073874267 @default.
• W2019424369 cites W2074969851 @default.
• W2019424369 cites W2076803670 @default.
• W2019424369 cites W2079542677 @default.
• W2019424369 cites W2082173837 @default.
• W2019424369 cites W2083424266 @default.
• W2019424369 cites W2092629366 @default.
• W2019424369 cites W2108724513 @default.
• W2019424369 cites W2128408747 @default.
• W2019424369 cites W2130642272 @default.
• W2019424369 cites W2163645221 @default.
• W2019424369 doi "https://doi.org/10.1016/s0192-0561(96)00065-3" @default.
• W2019424369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9080250" @default.
• W2019424369 hasPublicationYear "1996" @default.
• W2019424369 type Work @default.
• W2019424369 sameAs 2019424369 @default.
• W2019424369 citedByCount "7" @default.
• W2019424369 countsByYear W20194243692017 @default.
• W2019424369 countsByYear W20194243692018 @default.
• W2019424369 crossrefType "journal-article" @default.
• W2019424369 hasAuthorship W2019424369A5003492189 @default.
• W2019424369 hasAuthorship W2019424369A5011703773 @default.
• W2019424369 hasAuthorship W2019424369A5045015927 @default.
• W2019424369 hasAuthorship W2019424369A5047813375 @default.
• W2019424369 hasAuthorship W2019424369A5079557352 @default.
• W2019424369 hasConcept C104317684 @default.
• W2019424369 hasConcept C147483822 @default.
• W2019424369 hasConcept C153911025 @default.
• W2019424369 hasConcept C154317977 @default.
• W2019424369 hasConcept C159047783 @default.
• W2019424369 hasConcept C167625842 @default.
• W2019424369 hasConcept C167672396 @default.
• W2019424369 hasConcept C187882448 @default.
• W2019424369 hasConcept C195616568 @default.
• W2019424369 hasConcept C202751555 @default.
• W2019424369 hasConcept C203014093 @default.
• W2019424369 hasConcept C207936829 @default.
• W2019424369 hasConcept C2779281246 @default.
• W2019424369 hasConcept C55493867 @default.
• W2019424369 hasConcept C86803240 @default.
• W2019424369 hasConceptScore W2019424369C104317684 @default.
• W2019424369 hasConceptScore W2019424369C147483822 @default.
• W2019424369 hasConceptScore W2019424369C153911025 @default.
• W2019424369 hasConceptScore W2019424369C154317977 @default.
• W2019424369 hasConceptScore W2019424369C159047783 @default.
• W2019424369 hasConceptScore W2019424369C167625842 @default.
• W2019424369 hasConceptScore W2019424369C167672396 @default.
• W2019424369 hasConceptScore W2019424369C187882448 @default.
• W2019424369 hasConceptScore W2019424369C195616568 @default.
• W2019424369 hasConceptScore W2019424369C202751555 @default.
• W2019424369 hasConceptScore W2019424369C203014093 @default.
• W2019424369 hasConceptScore W2019424369C207936829 @default.
• W2019424369 hasConceptScore W2019424369C2779281246 @default.
• W2019424369 hasConceptScore W2019424369C55493867 @default.
• W2019424369 hasConceptScore W2019424369C86803240 @default.
• W2019424369 hasIssue "10" @default.
• W2019424369 hasLocation W20194243691 @default.
• W2019424369 hasLocation W20194243692 @default.
• W2019424369 hasOpenAccess W2019424369 @default.
• W2019424369 hasPrimaryLocation W20194243691 @default.
• W2019424369 hasRelatedWork W1501710489 @default.
• W2019424369 hasRelatedWork W1674854702 @default.
• W2019424369 hasRelatedWork W1989247143 @default.
• W2019424369 hasRelatedWork W2009390410 @default.
• W2019424369 hasRelatedWork W2015157953 @default.
• W2019424369 hasRelatedWork W2052483994 @default.
• W2019424369 hasRelatedWork W2136815099 @default.
• W2019424369 hasRelatedWork W2147236666 @default.
• W2019424369 hasRelatedWork W2797003224 @default.
• W2019424369 hasRelatedWork W4307243769 @default.
• W2019424369 hasVolume "18" @default.
• W2019424369 isParatext "false" @default.
• W2019424369 isRetracted "false" @default.
• W2019424369 magId "2019424369" @default.

• next