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- W2019424595 abstract "Expression of flavin-containing monooxygenase (FMO) activity has been shown to be directly correlated with salinity in euryhaline fish. Sex steroids play a significant role in osmoregulation in euryhaline fish. The effects of 17 beta-estradiol and testosterone on hepatic FMO activity (N,N-dimethylaniline N-oxygenase; thiourea S-oxygenase) and expression was examined in 6-month-old and 1-year-old rainbow trout (Oncorhynchus mykiss). Fish were treated with 3 mg/kg of each compound on days 1, 4, 7, 10, 13, and 15 with euthanasia on day 19. Treatment of 6-month-old and 1-year-old female rainbow trout with testosterone or estradiol significantly reduced FMO-catalyzed DMA N-oxygenase activity in liver. However, testosterone treatment failed to significantly alter thiourea S-oxidase in 1-year-old males, although 17 beta-estradiol significantly reduced FMO activity. These results parallel those of studies showing repressive effects of sex steroids on branchial chloride cells and Na+K+ATPase of salmonids and provide further evidence of a role for FMO in teleost osmoregulation." @default.
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- W2019424595 title "Down regulation of hepatic flavin-containing monooxygenase activity by 17β-estradiol in rainbow trout (Oncorhynchus mykiss)" @default.
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- W2019424595 doi "https://doi.org/10.1016/s0742-8413(97)00139-4" @default.
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