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- W2019425632 endingPage "204" @default.
- W2019425632 startingPage "190" @default.
- W2019425632 abstract "There is renewed interest in phenotypic approaches to drug discovery, using cell-based assays to select new drugs, with the goal of improving pharmaceutical success. Assays that are more predictive of human biology can help researchers achieve this goal. Primary cells are more physiologically relevant to human biology and advances are being made in methods to expand the available cell types and improve the potential clinical translation of these assays through the use of co-cultures or three-dimensional (3D) technologies. Of particular interest are assays that may be suitable for industrial scale drug discovery. Here we review the use of primary human cells and co-cultures in drug discovery and describe the characteristics of co-culture models for inflammation biology (BioMAP systems), neo-vascularization and tumor microenvironments. Finally we briefly describe technical trends that may enable and impact the development of physiologically relevant co-culture assays in the near future." @default.
- W2019425632 created "2016-06-24" @default.
- W2019425632 creator A5006696624 @default.
- W2019425632 creator A5021215331 @default.
- W2019425632 creator A5047545305 @default.
- W2019425632 date "2014-04-01" @default.
- W2019425632 modified "2023-09-30" @default.
- W2019425632 title "Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery" @default.
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