FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019425845> ?p ?o ?g. }

• W2019425845 endingPage "60" @default.
• W2019425845 startingPage "47" @default.
• W2019425845 abstract "Recently, it has become apparent that reactive oxygen species (ROS) play many important roles in biological systems. For example, relationships between many diseases, such as cancer, cardiac infarction and arteriosclerosis, and ROS have been found. It is also well known that anti-oxidative agents scavenge ROS in biological systems, which in turn prevents ROS-related diseases. In our previous efforts to develop effective anti-oxidative compounds, we found that 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), which is a hydroquinone monoalkyl ether, is a potent anti-oxidative agent. Here, the scavenging activities of HTHQ against ROS, such as superoxide anion radicals, hydroxyl radicals, t-butyl peroxyl radicals and singlet oxygens, were examined by the ESR (electron spin resonance)-spin trapping method. Among ROS, HTHQ scavenged t-butyl peroxyl radicals most effectively (IC50=0.31±0.04 mM), showing approximately twice the activity of a well-known lipophilic anti-oxidant, d,l-α-tocopherol (IC50=0.67±0.06 mM), as measured by IC50 values defined as the 50% inhibition concentration of the generated ROS. In addition, a relatively stable ESR spectrum of free radicals due to HTHQ was observed during the reaction of HTHQ and t-butyl peroxyl radicals, indicating a direct reaction of HTHQ and t-butyl peroxyl radicals. The free radicals due to HTHQ were more stable than those derived from d,l-α-tocopherol under the same conditions examined. On the basis of these results, we evaluated anti-lipid-peroxidative activity of HTHQ in three systems involving micelles, liposomes and rat liver microsomes. HTHQ exhibited a similar anti-oxidative activity to that of d,l-α-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. On the other hand, HTHQ exhibited approximately 4.8-fold higher anti-lipid-peroxidation activity than that of d,l-α-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+. Furthermore, HTHQ scavenged the lipid peroxides at a rate approximately 150 times higher than that of d,l-α-tocopherol against Fe3+-ADP-induced lipid peroxidation in rat liver microsomes, indicating that the anti-lipid-peroxidation activity of HTHQ might be substantially elevated in biological systems in comparison with that of d,l-α-tocopherol. Based on these results, we suggest that HTHQ reacts directly with peroxyl radicals, such as t-butyl peroxyl radicals and peroxides of linolate micelles, liposomes and microsomes, by scavenging them to form stable free radicals. The resulting free radicals are presumed to be reduced by several reducing mechanisms in biological systems similarly to those of d,l-α-tocopherol, and then the lipid-peroxidation reactions will be terminated. In conclusion, HTHQ was found to be a potent anti-lipid-peroxidative compound and its anti-oxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals. We propose that HTHQ is a potent anti-oxidative agent for use in future treatments for lipid-peroxide relevant diseases." @default.
• W2019425845 created "2016-06-24" @default.
• W2019425845 creator A5008610426 @default.
• W2019425845 creator A5040608142 @default.
• W2019425845 creator A5065473510 @default.
• W2019425845 creator A5066083647 @default.
• W2019425845 creator A5087564630 @default.
• W2019425845 date "1998-09-01" @default.
• W2019425845 modified "2023-10-09" @default.
• W2019425845 title "HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations" @default.
• W2019425845 cites W11800257 @default.
• W2019425845 cites W130300138 @default.
• W2019425845 cites W1486525201 @default.
• W2019425845 cites W1491877983 @default.
• W2019425845 cites W1497458285 @default.
• W2019425845 cites W1504654220 @default.
• W2019425845 cites W1548078249 @default.
• W2019425845 cites W1573704697 @default.
• W2019425845 cites W1585843744 @default.
• W2019425845 cites W1595015475 @default.
• W2019425845 cites W1604764621 @default.
• W2019425845 cites W1879184430 @default.
• W2019425845 cites W188297114 @default.
• W2019425845 cites W1966318176 @default.
• W2019425845 cites W196714009 @default.
• W2019425845 cites W1969902663 @default.
• W2019425845 cites W1972774373 @default.
• W2019425845 cites W1975302032 @default.
• W2019425845 cites W1982915064 @default.
• W2019425845 cites W1983310681 @default.
• W2019425845 cites W1985752187 @default.
• W2019425845 cites W1993508370 @default.
• W2019425845 cites W1996575997 @default.
• W2019425845 cites W2001510074 @default.
• W2019425845 cites W2002488252 @default.
• W2019425845 cites W2003379736 @default.
• W2019425845 cites W2006964247 @default.
• W2019425845 cites W2008046525 @default.
• W2019425845 cites W2008836533 @default.
• W2019425845 cites W2009319388 @default.
• W2019425845 cites W2012441627 @default.
• W2019425845 cites W2020448762 @default.
• W2019425845 cites W2021555767 @default.
• W2019425845 cites W2024921655 @default.
• W2019425845 cites W2033381823 @default.
• W2019425845 cites W2040660829 @default.
• W2019425845 cites W2048487276 @default.
• W2019425845 cites W2048966030 @default.
• W2019425845 cites W2052932750 @default.
• W2019425845 cites W2054226158 @default.
• W2019425845 cites W2055479342 @default.
• W2019425845 cites W2055858966 @default.
• W2019425845 cites W2056168344 @default.
• W2019425845 cites W2057522312 @default.
• W2019425845 cites W2060194897 @default.
• W2019425845 cites W2062545960 @default.
• W2019425845 cites W2067668489 @default.
• W2019425845 cites W2069234570 @default.
• W2019425845 cites W2093841643 @default.
• W2019425845 cites W2101511034 @default.
• W2019425845 cites W2110569594 @default.
• W2019425845 cites W2124911515 @default.
• W2019425845 cites W2147239346 @default.
• W2019425845 cites W2152719751 @default.
• W2019425845 cites W2189696737 @default.
• W2019425845 cites W2201784617 @default.
• W2019425845 cites W2323269165 @default.
• W2019425845 cites W2326798997 @default.
• W2019425845 cites W2398455818 @default.
• W2019425845 cites W79019264 @default.
• W2019425845 doi "https://doi.org/10.1016/s0304-4165(98)00050-6" @default.
• W2019425845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9813237" @default.
• W2019425845 hasPublicationYear "1998" @default.
• W2019425845 type Work @default.
• W2019425845 sameAs 2019425845 @default.
• W2019425845 citedByCount "25" @default.
• W2019425845 countsByYear W20194258452012 @default.
• W2019425845 countsByYear W20194258452015 @default.
• W2019425845 countsByYear W20194258452016 @default.
• W2019425845 countsByYear W20194258452017 @default.
• W2019425845 countsByYear W20194258452019 @default.
• W2019425845 countsByYear W20194258452020 @default.
• W2019425845 countsByYear W20194258452021 @default.
• W2019425845 crossrefType "journal-article" @default.
• W2019425845 hasAuthorship W2019425845A5008610426 @default.
• W2019425845 hasAuthorship W2019425845A5040608142 @default.
• W2019425845 hasAuthorship W2019425845A5065473510 @default.
• W2019425845 hasAuthorship W2019425845A5066083647 @default.
• W2019425845 hasAuthorship W2019425845A5087564630 @default.
• W2019425845 hasConcept C121332964 @default.
• W2019425845 hasConcept C139066938 @default.
• W2019425845 hasConcept C155647269 @default.
• W2019425845 hasConcept C178790620 @default.
• W2019425845 hasConcept C181199279 @default.
• W2019425845 hasConcept C185592680 @default.
• W2019425845 hasConcept C187961010 @default.
• W2019425845 hasConcept C2778004101 @default.
• W2019425845 hasConcept C2778815226 @default.

• next