FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019426170> ?p ?o ?g. }

• W2019426170 endingPage "1107" @default.
• W2019426170 startingPage "1099" @default.
• W2019426170 abstract "ObjectiveThis study aimed to evaluate the structural benefit of a new biomaterial composed of alginate-chitosan (AC) beads dispersed in a hydrogel (H) derived from chitosan on the development of osteoarthritis (OA) in rabbit.DesignOA was induced by the surgical transection of the anterior cruciate ligament in rabbits. Animals received a single intra-articular injection (900 μl) of AC beads in H hydrogel, H hydrogel alone or saline a week after surgery. OA development was followed by X-rays. Blood samples were collected throughout the study to measure biological markers (Prostaglandins E2 – PGE2 and C reactive protein – CRP). Macroscopic observation and histological evaluation of articular cartilage and synovial membrane were performed 6 weeks after surgery.ResultsAC beads in H hydrogel prevented from the development of OA based on the reduction of the Kellgren & Lawrence (K&L) score. It also significantly reduced the histological score of cartilage lesion severity. This effect was homogenous on every joint compartment. It was due to a significant effect on cartilage structure and cellularity scores. The injection of AC beads in H hydrogel also tended to reduce the synovial membrane inflammation. No significant variation of biological markers was noted.ConclusionsThe present pilot study provides interesting and promising results for the use of AC beads in H hydrogel in animal. It indeed prevented the development of OA cartilage lesions without inflammatory signs. The potencies of this biomaterial to protect OA joint should be further documented. It could then represent a new alternative for viscosupplementation in human OA management." @default.
• W2019426170 created "2016-06-24" @default.
• W2019426170 creator A5012454701 @default.
• W2019426170 creator A5014497585 @default.
• W2019426170 creator A5050755647 @default.
• W2019426170 creator A5061657475 @default.
• W2019426170 creator A5077969840 @default.
• W2019426170 date "2013-08-01" @default.
• W2019426170 modified "2023-09-25" @default.
• W2019426170 title "Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular injection of alginate-chitosan beads dispersed in an hydrogel" @default.
• W2019426170 cites W1551310212 @default.
• W2019426170 cites W1964058689 @default.
• W2019426170 cites W1965665343 @default.
• W2019426170 cites W1977737380 @default.
• W2019426170 cites W2008714459 @default.
• W2019426170 cites W2010575269 @default.
• W2019426170 cites W2015884061 @default.
• W2019426170 cites W2024959837 @default.
• W2019426170 cites W2029720037 @default.
• W2019426170 cites W2040604839 @default.
• W2019426170 cites W2041001892 @default.
• W2019426170 cites W2045253420 @default.
• W2019426170 cites W2045643354 @default.
• W2019426170 cites W2053738676 @default.
• W2019426170 cites W2055973157 @default.
• W2019426170 cites W2061977935 @default.
• W2019426170 cites W2065386894 @default.
• W2019426170 cites W2065587003 @default.
• W2019426170 cites W2067317498 @default.
• W2019426170 cites W2069937597 @default.
• W2019426170 cites W2077930888 @default.
• W2019426170 cites W2079566560 @default.
• W2019426170 cites W2089645152 @default.
• W2019426170 cites W2096648574 @default.
• W2019426170 cites W2105081941 @default.
• W2019426170 cites W2113079259 @default.
• W2019426170 cites W2113737049 @default.
• W2019426170 cites W2115041793 @default.
• W2019426170 cites W2115805053 @default.
• W2019426170 cites W2118567612 @default.
• W2019426170 cites W2122435770 @default.
• W2019426170 cites W2132865989 @default.
• W2019426170 cites W2158488933 @default.
• W2019426170 cites W2167792025 @default.
• W2019426170 cites W2188180894 @default.
• W2019426170 cites W2610860323 @default.
• W2019426170 cites W4233408642 @default.
• W2019426170 cites W4244240406 @default.
• W2019426170 cites W4248226706 @default.
• W2019426170 cites W4367363094 @default.
• W2019426170 doi "https://doi.org/10.1016/j.joca.2013.04.017" @default.
• W2019426170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23680875" @default.
• W2019426170 hasPublicationYear "2013" @default.
• W2019426170 type Work @default.
• W2019426170 sameAs 2019426170 @default.
• W2019426170 citedByCount "32" @default.
• W2019426170 countsByYear W20194261702014 @default.
• W2019426170 countsByYear W20194261702015 @default.
• W2019426170 countsByYear W20194261702016 @default.
• W2019426170 countsByYear W20194261702017 @default.
• W2019426170 countsByYear W20194261702018 @default.
• W2019426170 countsByYear W20194261702019 @default.
• W2019426170 countsByYear W20194261702020 @default.
• W2019426170 countsByYear W20194261702021 @default.
• W2019426170 countsByYear W20194261702022 @default.
• W2019426170 crossrefType "journal-article" @default.
• W2019426170 hasAuthorship W2019426170A5012454701 @default.
• W2019426170 hasAuthorship W2019426170A5014497585 @default.
• W2019426170 hasAuthorship W2019426170A5050755647 @default.
• W2019426170 hasAuthorship W2019426170A5061657475 @default.
• W2019426170 hasAuthorship W2019426170A5077969840 @default.
• W2019426170 hasBestOaLocation W20194261701 @default.
• W2019426170 hasConcept C105702510 @default.
• W2019426170 hasConcept C126322002 @default.
• W2019426170 hasConcept C136229726 @default.
• W2019426170 hasConcept C142724271 @default.
• W2019426170 hasConcept C185592680 @default.
• W2019426170 hasConcept C204787440 @default.
• W2019426170 hasConcept C2776164576 @default.
• W2019426170 hasConcept C2776914184 @default.
• W2019426170 hasConcept C2777564180 @default.
• W2019426170 hasConcept C2777652487 @default.
• W2019426170 hasConcept C2778414984 @default.
• W2019426170 hasConcept C2779732960 @default.
• W2019426170 hasConcept C2780550940 @default.
• W2019426170 hasConcept C2781032047 @default.
• W2019426170 hasConcept C2909830753 @default.
• W2019426170 hasConcept C3019843197 @default.
• W2019426170 hasConcept C3020332539 @default.
• W2019426170 hasConcept C55493867 @default.
• W2019426170 hasConcept C71924100 @default.
• W2019426170 hasConceptScore W2019426170C105702510 @default.
• W2019426170 hasConceptScore W2019426170C126322002 @default.
• W2019426170 hasConceptScore W2019426170C136229726 @default.
• W2019426170 hasConceptScore W2019426170C142724271 @default.
• W2019426170 hasConceptScore W2019426170C185592680 @default.
• W2019426170 hasConceptScore W2019426170C204787440 @default.
• W2019426170 hasConceptScore W2019426170C2776164576 @default.

• next