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- W2019427760 abstract "Fully grown immature oocytes acquire the ability to be fertilized with sperm after meiotic maturation, which is finally accomplished by the formation and activation of the maturation-promoting factor (MPF). MPF is the complex of Cdc2 and cyclin B, and its function in promoting metaphase is common among species. The Mos/mitogen-activated protein kinase (MAPK) pathway is also commonly activated during vertebrate oocyte maturation, but its function seems to be different among species. We investigated the function of the Mos/MAPK pathway during oocyte maturation of the frog Rana japonica. Although MAPK was activated in accordance with MPF activation during oocyte maturation, MPF activation and germinal vesicle breakdown (GVBD) was not initiated when the Mos/MAPK pathway was activated in immature oocytes by the injection of c-mos mRNA. Inhibition of Mos synthesis by c-mos antisense RNA and inactivation of MAPK by CL100 phosphatase did not prevent progesterone-induced MPF activation and GVBD. However, continuous MAPK activation and MAPK inhibition through oocyte maturation accelerated and delayed MPF activation, respectively. Furthermore, Mos induced a low level of cyclin B protein synthesis in immature oocytes without the aid of MAPK. These results suggest that the general function of the Mos/MAPK pathway, which is not essential for MPF activation and GVBD in Rana oocytes, is to enhance cyclin B translation by Mos itself and to stabilize cyclin B protein by MAPK during oocyte maturation." @default.
- W2019427760 created "2016-06-24" @default.
- W2019427760 creator A5055575842 @default.
- W2019427760 creator A5061728715 @default.
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- W2019427760 date "2000-01-01" @default.
- W2019427760 modified "2023-10-13" @default.
- W2019427760 title "Function of the Mos/MAPK pathway during oocyte maturation in the Japanese brown frogRana japonica" @default.
- W2019427760 cites W1528752018 @default.
- W2019427760 cites W1595865541 @default.
- W2019427760 cites W1597498191 @default.
- W2019427760 cites W1601079227 @default.
- W2019427760 cites W1723327061 @default.
- W2019427760 cites W1835631123 @default.
- W2019427760 cites W1961412795 @default.
- W2019427760 cites W1968283108 @default.
- W2019427760 cites W1969039586 @default.
- W2019427760 cites W1971946065 @default.
- W2019427760 cites W1972979813 @default.
- W2019427760 cites W1977299280 @default.
- W2019427760 cites W1977677084 @default.
- W2019427760 cites W1982752345 @default.
- W2019427760 cites W1984269514 @default.
- W2019427760 cites W1989730199 @default.
- W2019427760 cites W1993995783 @default.
- W2019427760 cites W1996413533 @default.
- W2019427760 cites W2004446962 @default.
- W2019427760 cites W2007443016 @default.
- W2019427760 cites W2009047529 @default.
- W2019427760 cites W2010051771 @default.
- W2019427760 cites W2011245371 @default.
- W2019427760 cites W2011802485 @default.
- W2019427760 cites W2012130857 @default.
- W2019427760 cites W2012781224 @default.
- W2019427760 cites W2013549179 @default.
- W2019427760 cites W2014234155 @default.
- W2019427760 cites W2015150670 @default.
- W2019427760 cites W2018636110 @default.
- W2019427760 cites W2020946972 @default.
- W2019427760 cites W2025794474 @default.
- W2019427760 cites W2026466385 @default.
- W2019427760 cites W2026663492 @default.
- W2019427760 cites W2031576542 @default.
- W2019427760 cites W2032451459 @default.
- W2019427760 cites W2032840077 @default.
- W2019427760 cites W2033271918 @default.
- W2019427760 cites W2037060834 @default.
- W2019427760 cites W2044752245 @default.
- W2019427760 cites W2050039745 @default.
- W2019427760 cites W2050688761 @default.
- W2019427760 cites W2054760302 @default.
- W2019427760 cites W2057472068 @default.
- W2019427760 cites W2057811505 @default.
- W2019427760 cites W2064755731 @default.
- W2019427760 cites W2067486558 @default.
- W2019427760 cites W2069075989 @default.
- W2019427760 cites W2070061120 @default.
- W2019427760 cites W2073239182 @default.
- W2019427760 cites W2075646637 @default.
- W2019427760 cites W2076380924 @default.
- W2019427760 cites W2085593164 @default.
- W2019427760 cites W2089218510 @default.
- W2019427760 cites W2092104789 @default.
- W2019427760 cites W2093205464 @default.
- W2019427760 cites W2102242413 @default.
- W2019427760 cites W2102502366 @default.
- W2019427760 cites W2107423274 @default.
- W2019427760 cites W2115701574 @default.
- W2019427760 cites W2117800241 @default.
- W2019427760 cites W2117939247 @default.
- W2019427760 cites W2124541962 @default.
- W2019427760 cites W2127328198 @default.
- W2019427760 cites W2130084958 @default.
- W2019427760 cites W2132911221 @default.
- W2019427760 cites W2137179640 @default.
- W2019427760 cites W2141678226 @default.
- W2019427760 cites W2145312934 @default.
- W2019427760 cites W2154625613 @default.
- W2019427760 cites W2165040380 @default.
- W2019427760 cites W2196561685 @default.
- W2019427760 cites W247355068 @default.
- W2019427760 cites W271731697 @default.
- W2019427760 cites W278881652 @default.
- W2019427760 cites W41535097 @default.
- W2019427760 cites W98119722 @default.
- W2019427760 doi "https://doi.org/10.1002/1098-2795(200009)57:1<88::aid-mrd12>3.0.co;2-9" @default.
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