Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019430480> ?p ?o ?g. }
- W2019430480 endingPage "101" @default.
- W2019430480 startingPage "94" @default.
- W2019430480 abstract "The present work was proposed not only to exploit the potential of 3D cage-like mesoporous silica SBA-16 with a well-defined spherical morphology as a carrier for poorly soluble drugs, but also to compare the drug loading and release properties of 3D cubic SBA-16 with that of classic 2D hexagonal MCM-41. SBA-16 microsphere with highly ordered mesostructures was synthesized by a facile method using block co-polymer F127 as template, cetyltrimethylammonium bromide (CTAB) as co-template and tetraethyl orthosilicate (TEOS) as silica source. Carvedilol (CAR), an antihypertensive agent, was used as a model drug and loaded into mesoporous silica via solvent deposition method at drug–silica ratio of 1:3. In vitro dissolution was performed in both simulated intestinal fluid (SIF, pH 6.8) and simulated gastric fluid (SGF, pH 1.2). Of particular interest was that in SIF both MCM-41 and SBA-16 samples exhibited promoted dissolution profile for CAR as compared to its corresponding crystalline form which exhibited poor dissolution behavior. This dissolution-enhancing effect might be due to the non-crystalline state and increased surface area of confined CAR as well as the hydrophilic nature of silica. In comparison with MCM-41, SBA-16 displayed a more rapid release profile in both SIF and SGF, which may be ascribed to the 3D interconnected pore networks and the highly accessible surface areas. The suitability of the utilization of SBA-16 microsphere as carriers will open new avenues for the formulation of poorly soluble drugs." @default.
- W2019430480 created "2016-06-24" @default.
- W2019430480 creator A5019409268 @default.
- W2019430480 creator A5023864012 @default.
- W2019430480 creator A5033601360 @default.
- W2019430480 creator A5055016331 @default.
- W2019430480 creator A5059028304 @default.
- W2019430480 creator A5061523947 @default.
- W2019430480 creator A5070730662 @default.
- W2019430480 creator A5086859874 @default.
- W2019430480 date "2012-01-01" @default.
- W2019430480 modified "2023-09-30" @default.
- W2019430480 title "3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol" @default.
- W2019430480 cites W1554026412 @default.
- W2019430480 cites W1590254871 @default.
- W2019430480 cites W1964107229 @default.
- W2019430480 cites W1973042607 @default.
- W2019430480 cites W1979884568 @default.
- W2019430480 cites W1981191557 @default.
- W2019430480 cites W1981953367 @default.
- W2019430480 cites W1991380265 @default.
- W2019430480 cites W1991914198 @default.
- W2019430480 cites W1995041236 @default.
- W2019430480 cites W1995530669 @default.
- W2019430480 cites W1996811879 @default.
- W2019430480 cites W2000505705 @default.
- W2019430480 cites W2007790188 @default.
- W2019430480 cites W2015631141 @default.
- W2019430480 cites W2020909046 @default.
- W2019430480 cites W2021479394 @default.
- W2019430480 cites W2024881308 @default.
- W2019430480 cites W2025857105 @default.
- W2019430480 cites W2027796851 @default.
- W2019430480 cites W2031647459 @default.
- W2019430480 cites W2034791599 @default.
- W2019430480 cites W2035088903 @default.
- W2019430480 cites W2039083422 @default.
- W2019430480 cites W2041099388 @default.
- W2019430480 cites W2042109441 @default.
- W2019430480 cites W2042602209 @default.
- W2019430480 cites W2044230192 @default.
- W2019430480 cites W2052784248 @default.
- W2019430480 cites W2057184167 @default.
- W2019430480 cites W2058293286 @default.
- W2019430480 cites W2058586695 @default.
- W2019430480 cites W2058783557 @default.
- W2019430480 cites W2068184948 @default.
- W2019430480 cites W2070517548 @default.
- W2019430480 cites W2071913543 @default.
- W2019430480 cites W2072864417 @default.
- W2019430480 cites W2073595990 @default.
- W2019430480 cites W2077548169 @default.
- W2019430480 cites W2081095452 @default.
- W2019430480 cites W2083835258 @default.
- W2019430480 cites W2084596745 @default.
- W2019430480 cites W2086705246 @default.
- W2019430480 cites W2086734201 @default.
- W2019430480 cites W2090440408 @default.
- W2019430480 cites W2111718136 @default.
- W2019430480 cites W2124030287 @default.
- W2019430480 cites W2128086052 @default.
- W2019430480 cites W2129440175 @default.
- W2019430480 cites W2147644734 @default.
- W2019430480 cites W2152752812 @default.
- W2019430480 cites W4809102 @default.
- W2019430480 doi "https://doi.org/10.1016/j.micromeso.2011.06.001" @default.
- W2019430480 hasPublicationYear "2012" @default.
- W2019430480 type Work @default.
- W2019430480 sameAs 2019430480 @default.
- W2019430480 citedByCount "114" @default.
- W2019430480 countsByYear W20194304802012 @default.
- W2019430480 countsByYear W20194304802013 @default.
- W2019430480 countsByYear W20194304802014 @default.
- W2019430480 countsByYear W20194304802015 @default.
- W2019430480 countsByYear W20194304802016 @default.
- W2019430480 countsByYear W20194304802017 @default.
- W2019430480 countsByYear W20194304802018 @default.
- W2019430480 countsByYear W20194304802019 @default.
- W2019430480 countsByYear W20194304802020 @default.
- W2019430480 countsByYear W20194304802021 @default.
- W2019430480 countsByYear W20194304802022 @default.
- W2019430480 countsByYear W20194304802023 @default.
- W2019430480 crossrefType "journal-article" @default.
- W2019430480 hasAuthorship W2019430480A5019409268 @default.
- W2019430480 hasAuthorship W2019430480A5023864012 @default.
- W2019430480 hasAuthorship W2019430480A5033601360 @default.
- W2019430480 hasAuthorship W2019430480A5055016331 @default.
- W2019430480 hasAuthorship W2019430480A5059028304 @default.
- W2019430480 hasAuthorship W2019430480A5061523947 @default.
- W2019430480 hasAuthorship W2019430480A5070730662 @default.
- W2019430480 hasAuthorship W2019430480A5086859874 @default.
- W2019430480 hasConcept C114874019 @default.
- W2019430480 hasConcept C127413603 @default.
- W2019430480 hasConcept C13245373 @default.
- W2019430480 hasConcept C159985019 @default.
- W2019430480 hasConcept C161790260 @default.
- W2019430480 hasConcept C171250308 @default.
- W2019430480 hasConcept C178790620 @default.