Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019432938> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2019432938 endingPage "2164" @default.
- W2019432938 startingPage "2159" @default.
- W2019432938 abstract "HIC-1 (hypermethylated in cancer) is a candidate tumor suppressor gene which is located at 17p13.3, a region which frequently undergoes allelic loss in breast and other human cancers. HIC-1 is proposed to be commonly inactivated in human cancers by hypermethylation of a normally unmethylated dense CpG island which encompasses the entire gene. To study whether HIC-1 inactivation may be important to the development of breast cancer, we first measured methylation of the HIC-1 gene in normal breast ductal tissues from microdissected frozen breast tissues and from epithelial cells purified from mammoplasty specimens. Surprisingly, in all normal breast ductal tissues we found approximately equal amounts of densely methylated HIC-1 and completely unmethylated HIC-1. This is in contrast to most normal tissues, in which all copies of HIC-1 are completely unmethylated. We then evaluated 39 primary breast cancer tissues and found virtually complete methylation of the HIC-1 gene in 26 (67%) of the cases. We also found loss of heterozygosity at the telomeric portion of chromosomal arm 17p in 22 of the 26 cases with strongly methylated HIC-1, suggesting that loss of an unmethylated HIC-1 allele may contribute to the inactivation of HIC-1 in cells with a pre-existing methylated allele. Finally, by RNase protection analysis, HIC-1 was found to be expressed in microdissected normal breast ductal tissues and unmethylated tumors but not in tumors with hypermethylation of the HIC-1 gene. These results indicate that hypermethylation of HIC-1 and associated loss of HIC-1 expression is common in primary breast cancer. Furthermore, the HIC-1 gene is densely methylated in approximately one-half of the alleles in normal breast epithelium, which may predispose this tissue to inactivation of this gene by loss of heterozygosity." @default.
- W2019432938 created "2016-06-24" @default.
- W2019432938 creator A5013692589 @default.
- W2019432938 creator A5020410968 @default.
- W2019432938 creator A5021598968 @default.
- W2019432938 creator A5033331004 @default.
- W2019432938 creator A5058612163 @default.
- W2019432938 creator A5083467309 @default.
- W2019432938 date "1998-04-23" @default.
- W2019432938 modified "2023-09-30" @default.
- W2019432938 title "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer" @default.
- W2019432938 cites W2037017084 @default.
- W2019432938 doi "https://doi.org/10.1038/sj.onc.1201976" @default.
- W2019432938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9572497" @default.
- W2019432938 hasPublicationYear "1998" @default.
- W2019432938 type Work @default.
- W2019432938 sameAs 2019432938 @default.
- W2019432938 citedByCount "140" @default.
- W2019432938 countsByYear W20194329382012 @default.
- W2019432938 countsByYear W20194329382013 @default.
- W2019432938 countsByYear W20194329382014 @default.
- W2019432938 countsByYear W20194329382015 @default.
- W2019432938 countsByYear W20194329382016 @default.
- W2019432938 countsByYear W20194329382017 @default.
- W2019432938 countsByYear W20194329382018 @default.
- W2019432938 countsByYear W20194329382019 @default.
- W2019432938 countsByYear W20194329382020 @default.
- W2019432938 countsByYear W20194329382021 @default.
- W2019432938 countsByYear W20194329382023 @default.
- W2019432938 crossrefType "journal-article" @default.
- W2019432938 hasAuthorship W2019432938A5013692589 @default.
- W2019432938 hasAuthorship W2019432938A5020410968 @default.
- W2019432938 hasAuthorship W2019432938A5021598968 @default.
- W2019432938 hasAuthorship W2019432938A5033331004 @default.
- W2019432938 hasAuthorship W2019432938A5058612163 @default.
- W2019432938 hasAuthorship W2019432938A5083467309 @default.
- W2019432938 hasBestOaLocation W20194329381 @default.
- W2019432938 hasConcept C104317684 @default.
- W2019432938 hasConcept C121608353 @default.
- W2019432938 hasConcept C140173407 @default.
- W2019432938 hasConcept C143589142 @default.
- W2019432938 hasConcept C150194340 @default.
- W2019432938 hasConcept C153911025 @default.
- W2019432938 hasConcept C180754005 @default.
- W2019432938 hasConcept C190727270 @default.
- W2019432938 hasConcept C2778264664 @default.
- W2019432938 hasConcept C33288867 @default.
- W2019432938 hasConcept C502942594 @default.
- W2019432938 hasConcept C530470458 @default.
- W2019432938 hasConcept C54355233 @default.
- W2019432938 hasConcept C555283112 @default.
- W2019432938 hasConcept C86803240 @default.
- W2019432938 hasConceptScore W2019432938C104317684 @default.
- W2019432938 hasConceptScore W2019432938C121608353 @default.
- W2019432938 hasConceptScore W2019432938C140173407 @default.
- W2019432938 hasConceptScore W2019432938C143589142 @default.
- W2019432938 hasConceptScore W2019432938C150194340 @default.
- W2019432938 hasConceptScore W2019432938C153911025 @default.
- W2019432938 hasConceptScore W2019432938C180754005 @default.
- W2019432938 hasConceptScore W2019432938C190727270 @default.
- W2019432938 hasConceptScore W2019432938C2778264664 @default.
- W2019432938 hasConceptScore W2019432938C33288867 @default.
- W2019432938 hasConceptScore W2019432938C502942594 @default.
- W2019432938 hasConceptScore W2019432938C530470458 @default.
- W2019432938 hasConceptScore W2019432938C54355233 @default.
- W2019432938 hasConceptScore W2019432938C555283112 @default.
- W2019432938 hasConceptScore W2019432938C86803240 @default.
- W2019432938 hasIssue "16" @default.
- W2019432938 hasLocation W20194329381 @default.
- W2019432938 hasLocation W20194329382 @default.
- W2019432938 hasOpenAccess W2019432938 @default.
- W2019432938 hasPrimaryLocation W20194329381 @default.
- W2019432938 hasRelatedWork W1970892827 @default.
- W2019432938 hasRelatedWork W2014733545 @default.
- W2019432938 hasRelatedWork W2015465252 @default.
- W2019432938 hasRelatedWork W2034502545 @default.
- W2019432938 hasRelatedWork W2051834296 @default.
- W2019432938 hasRelatedWork W2105272426 @default.
- W2019432938 hasRelatedWork W2110722443 @default.
- W2019432938 hasRelatedWork W2366961535 @default.
- W2019432938 hasRelatedWork W2594409179 @default.
- W2019432938 hasRelatedWork W2738735638 @default.
- W2019432938 hasVolume "16" @default.
- W2019432938 isParatext "false" @default.
- W2019432938 isRetracted "false" @default.
- W2019432938 magId "2019432938" @default.
- W2019432938 workType "article" @default.