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• W2019433333 abstract "As the result of early specification processes, sea urchin embryos eventually form various mesodermal cell lineages and a gut consisting of fore-, mid- and hindgut. The progression of specification as well as the overall spatial organization of the organism is encoded in its gene regulatory networks (GRNs). We have analyzed the GRN driving endoderm specification up to the onset of gastrulation and present in this paper the mechanisms which determine this process up to mid-blastula stage. At this stage, the embryo consists of two separate lineages of endoderm precursor cells with distinct regulatory states. One of these lineages, the veg2 cell lineage, gives rise to endoderm and mesoderm cell types. The separation of these cell fates is initiated by the spatially confined activation of the mesoderm GRN superimposed on a generally activated endoderm GRN within veg2 descendants. Here we integrate the architecture of regulatory interactions with the spatial restriction of regulatory gene expression to model the logic control of endoderm development." @default.
• W2019433333 created "2016-06-24" @default.
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• W2019433333 date "2010-04-01" @default.
• W2019433333 modified "2023-10-03" @default.
• W2019433333 title "The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage" @default.
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• W2019433333 doi "https://doi.org/10.1016/j.ydbio.2009.10.037" @default.
• W2019433333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3981691" @default.
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