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• W2019434736 abstract "To the Editor,A 41-year-old man was admitted to our hospital for investigation of a liver mass with extensive lymph node (LN) enlargement that was detected during follow-up abdominal computed tomography (CT) for chronic viral hepatitis B. Laboratory investigations showed a serum alanine aminotransferase level was 31 IU/L (normal range 10-40 IU/L), the aspartate aminotransferase level was 23 IU/L (normal range 6-40 IU/L) and the γ-glutamyltransferase level was 44 IU/L (normal range 5-63 IU/L). Alkaline phosphatase, total bilirubin and albumin levels were all within normal limits. The patient had an elevated serum α-fetoprotein level of 3580 ng/mL (normal range≤10 ng/mL) and a PIVKA-II level of 489 mAU/mL (normal range 0-40 mAU/mL); moreover, the carcinoembryonic antigen level was high level of 31.1 ng/mL (normal range 0-5 ng/mL). Serum hepatitis e antigen was negative and HBV PCR DNA level was 156 IU/mL. Abdominal CT showed hypodense mass, 2 cm, with necrosis at the medial portion, at the liver S7. Adding to this, CT demonstrated multiple conglomerated LN enlargement at the celiac axis, superior mesenteric artery (SMA), and para-aortic area (Fig. 1). In addition to CT, magnetic resonance imaging (MRI) also showed 2 cm sized mass with necrosis at the medial portion, at the liver S7 and extensive LN enlargement. And FDG-PET/CT and chest CT were performed to evaluation of extrahepatic metastasis. FDG-PET/CT showed isometaoblic mass, S7 of the liver with extensive LN metastasis at neck, axilla, mediastinum, and retroperitoneum (Fig. 1). Based on these findings, we could suspected hepatic lymphoma or combined hepatocellular and lymphoma and liver biopsy was performed for confirmation of liver mass. However, because of no evidence of malignancy on histologic findings of liver mass, cervical excisional LN biopsy was conducted. Histologic findings revealed metastatic hepatocellular carcinoma (HCC) and we confirmed small hepatocellular carcinoma with extensive LN metastasis (Fig. 2). Base upon the diagnosis of HCC metastasis to the LN, we started therapy with sorafenib. Two months later after sorafenib administration, an abdomen CT revealed new multiple hypodense masses with central necrosis at the liver and unfortunately, the patient died 3.5 months after the detection of the liver mass.Figure 1Abdomen computed tomography showed (A) hypodense mass, in 2.5 cm diameter in arterial phase and (B) multiple conglomerated LNs enlargement at the celiac axis, SMA, and paraaortic area. FDG-PET/CT showed (C) increased uptake of multiple LNs such as both ...Figure 2Microscopic findings of excisioned neck LN shows that (A) lymph node is replaced by tumor cell nests consisting of thick trabeculae with central tumor necrosis (H&E staining, ×40). (B) some tumor cells show positive reaction to HSA immunohistochemical ...The rate of extrahepatic metastases from hepatocellular carcinoma (HCC) is relatively lower than that in other hepatic cancers.1 Lymph node (LN) metastasis is observed in only 1.7% of patients undergoing surgery, but has been frequently observed in 30.7% of autopsies.2 It has been reported that small HCC, less than 2 cm in diameter, constitute approximately 15.6% of resectable HCC.3 Moreover, as a follow up of a high risk group of HCC using serum AFP and abdominal ultrasound is increased, early detection of resectable small HCC is increased so that in the case of small HCC, less than 2cm in diameter, is showing more than 50% of a 5-year survival rate.4Because LN metastasis of small HCC are very rare and good prognosis, the clinical significance has not well investigated and the relationship between the type of a primary HCC lesion and type of accompanying lymph node metastasis has not been documented. There is one study to investigate the relationship between the type of a primary HCC and the type of accompanying lymph node metastasis. Although all of the primary HCC lesions are not small HCC, they suggested that we need to consider that the type of the primary lesion is related to the pattern of lymph node metastasis and systemic exploration for lymph node metastasis is important, even for patients with small nodular type HCC.5Although diagnosis of small HCC has been increasing, there are lack of studies to investigate small HCC characteristics and prognosis. Therefore, further investigation should be needed to identify small HCC showing poor prognosis." @default.
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• W2019434736 date "2014-01-01" @default.
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• W2019434736 title "A case of small hepatocellular carcinoma with an extensive lymph node metastasis at diagnosis" @default.
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• W2019434736 doi "https://doi.org/10.3350/cmh.2014.20.3.310" @default.
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