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• W2019435006 abstract "This study demonstrates that rat Schwann cells can reactivate resting experimental allergic neuritis generating P2 and P2 peptide specific CD4+ T cell lines. T cell proliferation was significantly greater to P2 than to P2 peptide (SP-26) or ovalbumin (OA). Four-level analysis of variance showed that T cell proliferation with endogenous or exogenous P2 was not significantly different for Schwann cells plus cytokine IFN-γ (P = 0.5071) unlike P2 peptide or OA specific T cells (P = 0.0056 and 0.0003, respectively). Untreated Schwann cells were more effective inducers than irradiated or fixed Schwann cells. As stimulated CD4+ P2 T cells produce IFN-γ and TNF-α, this could exacerbate blood nerve barrier breakdown that has been increasingly implicated in inflammatory demyelinating neuropathies (IDNs). This would permit entry of antibodies and complement, thereby contributing to the demyelination process. Schwann cell induced reactivation of CD4+ T cells may therefore play a role in IDNs." @default.
• W2019435006 created "2016-06-24" @default.
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• W2019435006 date "1999-12-01" @default.
• W2019435006 modified "2023-09-27" @default.
• W2019435006 title "Restimulation of Resting Autoreactive T Cells by Schwann Cells in Vitro" @default.
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• W2019435006 doi "https://doi.org/10.1006/exmp.1999.2285" @default.
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